To Clip or Not to Clip: The Use of MitraClip Therapy for Functional Mitral Regurgitation.

Journal of Cardiothoracic and Vascular Anesthesia
Katelyn Devine, Richard Sheu

Abstract

Percutaneous edge-to-edge repair of the mitral valve with the MitraClip device has been shown to serve as a safe and effective treatment for severe mitral regurgitation in the high-risk surgical population. Although the device originally was designed for the reduction of degenerative mitral regurgitation resulting from primary leaflet abnormalities, numerous studies have included patients with functional mitral regurgitation from annular or ventricular distortion. Two recent landmark studies examined the use of the MitraClip device for functional mitral regurgitation treatment and found drastically opposing results. Data reconciliation by others has suggested only a subset of those with functional mitral regurgitation may benefit from this treatment. Herein 2 seemingly similar cases to illustrate the subtle differences in patient selection that eventually may change the clinical outcome for this procedure are presented.

References

Jun 17, 1998·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·F MaisanoO Alfieri
Jul 2, 2003·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·William A ZoghbiUNKNOWN American Society of Echocardiography
Sep 19, 2006·Lancet·Vuyisile T NkomoMaurice Enriquez-Sarano
Nov 15, 2011·Journal of the American College of Cardiology·Francesco MaisanoOttavio Alfieri
Aug 14, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Liliya ParanskayaHüseyin Ince
Aug 28, 2012·European Heart Journal·UNKNOWN Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC)Marian Zembala
Feb 12, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Michele De BonisOttavio Alfieri
Nov 9, 2016·International Journal of Cardiology·Hidehiro KanekoChristian Butter
Aug 28, 2018·The New England Journal of Medicine·Jean-François ObadiaUNKNOWN MITRA-FR Investigators
Sep 5, 2018·Journal of Cardiothoracic and Vascular Anesthesia·J Ross RenewHarish Ramakrishna
Oct 4, 2018·The New England Journal of Medicine·Gregg W StoneUNKNOWN COAPT Investigators
Dec 24, 2018·The New England Journal of Medicine·Rick A Nishimura, Robert O Bonow
May 23, 2019·European Heart Journal Cardiovascular Imaging·Philippe PibarotJeroen J Bax

❮ Previous
Next ❯

Citations

May 27, 2021·Case Reports in Anesthesiology·Tomoe SatohMichiaki Yamakage

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Interventional Cardiology Clinics
Alice Perlowski, Ted Feldman
Postępy w kardiologii interwencyjnej = Advances in interventional cardiology
Jerzy Pregowski, Adam Witkowski
© 2021 Meta ULC. All rights reserved