To discard or not to discard: the neural basis of hoarding symptoms in obsessive-compulsive disorder

Molecular Psychiatry
Suk Kyoon AnMary L Phillips

Abstract

Preliminary neuroimaging studies suggest that patients with the 'compulsive hoarding syndrome' may be a neurobiologically distinct variant of obsessive-compulsive disorder (OCD) but further research is needed. A total of 29 OCD patients (13 with and 16 without prominent hoarding symptoms) and 21 healthy controls of both sexes participated in two functional magnetic resonance imaging experiments consisting of the provocation of hoarding-related and symptom-unrelated (aversive control) anxiety. In response to the hoarding-related (but not symptom-unrelated) anxiety provocation, OCD patients with prominent hoarding symptoms showed greater activation in bilateral anterior ventromedial prefrontal cortex (VMPFC) than patients without hoarding symptoms and healthy controls. In the entire patient group (n=29), provoked anxiety was positively correlated with activation in a frontolimbic network that included the anterior VMPFC, medial temporal structures, thalamus and sensorimotor cortex. Negative correlations were observed in the left dorsal anterior cingulate gyrus, bilateral temporal cortex, bilateral dorsolateral/medial prefrontal regions, basal ganglia and parieto-occipital regions. These results were independent from the effects o...Continue Reading

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Nov 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Nov 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Mar 31, 1994·Behavioural Brain Research·C E Stern, R E Passingham
Apr 1, 1996·Behaviour Research and Therapy·R O Frost, T L Hartl
Jan 1, 1997·Magnetic Resonance Imaging·M J BrammerS Rabe-Hesketh
Feb 19, 1999·Lancet·L CohenC Pierrot-Deseilligny
Sep 25, 2001·Behavioural Neurology·Chris Rorden, Matthew Brett
Feb 13, 2002·Neurology·E VolleB Dubois
Dec 28, 2002·Psychological Assessment·Edna B FoaPaul M Salkovskis
Jul 26, 2003·NeuroImage·Ola FrimanHans Knutsson
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Nov 20, 2003·Clinical Psychology Review·Gail Steketee, Randy Frost
May 26, 2004·Progress in Neurobiology·Morten L Kringelbach, Edmund T Rolls
Jun 1, 2004·The American Journal of Psychiatry·Sanjaya SaxenaLewis R Baxter
Jun 9, 2004·Archives of General Psychiatry·David Mataix-ColsMary L Phillips
Sep 8, 2004·Behaviour Research and Therapy·Randy O FrostJessica Grisham
Sep 25, 2004·Depression and Anxiety·Tamara L HartlCary R Savage
Nov 19, 2004·Brain : a Journal of Neurology·Steven W AndersonAntonio R Damasio
Jan 8, 2005·Acta Psychiatrica Scandinavica·M OgaiN Takei
Jan 29, 2005·The American Journal of Psychiatry·David Mataix-ColsJames F Leckman
Mar 9, 2005·Archives of General Psychiatry·Odile A van den HeuvelRichard van Dyck
Sep 2, 2005·Nature Reviews. Neuroscience·Morten L Kringelbach
Jul 11, 2006·Behaviour Research and Therapy·Jack F SamuelsGerald Nestadt
May 15, 2007·NeuroImage·Mark E WaltonMatthew F S Rushworth
Aug 4, 2007·Behaviour Research and Therapy·Kiara R CromerDennis L Murphy
Sep 28, 2007·IEEE Transactions on Medical Imaging·Hua Li, Anthony Yezzi
Oct 12, 2007·Trends in Cognitive Sciences·Stephan F Taylor, Israel Liberzon

❮ Previous
Next ❯

Citations

Aug 8, 2012·Archives of General Psychiatry·David F TolinGodfrey D Pearlson
Jul 17, 2008·Current Psychiatry Reports·Sanjaya Saxena
Jul 3, 2013·Journal of Obsessive-compulsive and Related Disorders·Joseph F MeyerDavid F Tolin
Oct 13, 2009·Psychiatry Research·Humberto NicoliniJames L Kennedy
Feb 16, 2010·Behavioural and Cognitive Psychotherapy·Catherine SeamanPaul M Salkovskis
Aug 24, 2010·Psychiatry and Clinical Neurosciences·Hiromasa OhtsuchiYoshifumi Watanabe
Nov 3, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Joaquim Radua, David Mataix-Cols
Sep 21, 2011·Neuropsychiatric Disease and Treatment·Kelda H Walsh, Christopher J McDougle
Jul 9, 2013·Indian Journal of Psychological Medicine·Sri Mahavir AgarwalYemmigannur Chandrashekhar Janardhan Reddy
Jan 5, 2013·Behavioural and Cognitive Psychotherapy·Francesco BulliRandy O Frost
May 21, 2014·Nature Reviews. Neuroscience·David L PaulsDaniel A Geller
Dec 30, 2009·Journal of Autism and Developmental Disorders·Gideon E AnholtAnton J L M van Balkom
Nov 1, 2011·Annual Review of Clinical Psychology·Randy O FrostDavid F Tolin
Jun 2, 2012·Expert Opinion on Drug Discovery·Kurt Leroy Hoffman
Jan 3, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Christian RückDavid Mataix-Cols
Nov 22, 2011·Journal of Psychiatric Research·Kathrin KochRalf G M Schlösser
Jul 19, 2011·Psychiatry Research·David F TolinMatthew M Kurtz
Mar 2, 2010·Clinical Psychology Review·Alberto PertusaDavid Mataix-Cols
Sep 1, 2009·The Psychiatric Clinics of North America·Dan J SteinKatharine A Phillips
Oct 12, 2010·Journal of Anxiety Disorders·Danielle LandauDavid Mataix-Cols
Mar 2, 2011·Journal of Clinical Psychology·David F Tolin
Sep 8, 2011·Journal of Child Psychology and Psychiatry, and Allied Disciplines·David Mataix-Cols, Alberto Pertusa
Feb 26, 2011·Journal of Clinical Psychology·David Mataix-ColsJohn Snowdon
Feb 5, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Sean S O'SullivanAndrew D Lawrence
Jun 10, 2010·Depression and Anxiety·Katharine A PhillipsJames Leckman
Apr 26, 2014·Psychiatry and Clinical Neurosciences·Tomohiro NakaoShigenobu Kanba
Mar 26, 2010·Depression and Anxiety·David Mataix-ColsSabine Wilhelm
Jan 31, 2014·Psychiatry Research·Amanda M RainesNorman B Schmidt
Jan 29, 2014·Psychiatry Research·Sharon Morein-ZamirTrevor W Robbins
Oct 7, 2011·Behaviour Research and Therapy·David F Tolin, Anna Villavicencio
Feb 12, 2013·Neuron·Andres M Lozano, Nir Lipsman
May 6, 2014·Clinical Psychology Review·Sheila R WoodyAlison Welsted
Aug 3, 2010·Behaviour Research and Therapy·Alberto PertusaDavid Mataix-Cols
Apr 16, 2013·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Federica PirasGianfranco Spalletta
Nov 3, 2015·Acta Neuropsychiatrica·Tue HartmannPoul Videbech

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Related Papers

The American Journal of Psychiatry
Sanjaya SaxenaLewis R Baxter
The American Journal of Psychiatry
Alberto PertusaDavid Mataix-Cols
Behaviour Research and Therapy
Jessica R GrishamDavid H Barlow
Clinical Psychology Review
G Steketee, R O Frost
© 2021 Meta ULC. All rights reserved