To ICSI or Not to ICSI

Seminars in Reproductive Medicine
Gianpiero D PalermoZev Rosenwaks

Abstract

Intracytoplasmic sperm injection (ICSI) is the most effective assisted reproductive procedure enabling fertilization in severe forms of male factor indications and male gamete dysfunction. Reliability of ICSI has allowed the expansion of its application to other forms of infertility rendering it the most popular assisted reproduction technology (ART) insemination method worldwide. The concern related to the invasiveness of ICSI together with the arbitrary selection of the inseminating spermatozoon has induced the execution of studies to compare the performance of ICSI in non-male factor infertility with standard in vitro insemination approach. Not surprisingly, the outcome has evidenced that ICSI does not yield higher pregnancy rates than in vitro fertilization but functions invariably as a normalizer of fertilization mollifying the absent or low fertilization. The follow-up studies on ICSI children have evidenced that the procedure is safe and the slightly higher incidences of neonatal malformations or de novo gonosomal abnormalities are related to the genetics of the infertile couples. Furthermore, ICSI is accepted for some specific indications such as low number and poor morphology oocytes, thicker zona, excess polyspermia, ...Continue Reading

Citations

Dec 15, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Cesare AragonaMaria Salome Bezerra Espinola
Feb 21, 2016·Reproductive Biomedicine Online·Nigel PereiraZev Rosenwaks
Aug 17, 2016·Andrology·D T Carrell, C J De Jonge
Jan 11, 2017·Journal of Minimally Invasive Gynecology·Nigel PereiraZev Rosenwaks
Jul 19, 2015·American Journal of Men's Health·Douglas A MataRanjith Ramasamy
Oct 20, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Zev Rosenwaks, Nigel Pereira
Apr 11, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·C L O'NeillG D Palermo
Jul 16, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Nigel PereiraGianpiero D Palermo
Sep 7, 2018·Molecular Reproduction and Development·Jay SchinfeldAlexander J Travis
Jan 25, 2018·Human Fertility : Journal of the British Fertility Society·Niloofar ZiaratiMohammad Hossein Nasr Esfahani
Oct 16, 2019·Journal of Adolescent and Young Adult Oncology·Anthony N AudinoNicholas D Yeager
Sep 21, 2016·Systems Biology in Reproductive Medicine·Mara SimopoulouMichael Koutsilieris
Sep 27, 2019·BMJ : British Medical Journal·Yahia Al-JebariYvonne Lundberg Giwercman
Jul 4, 2018·Nature Reviews. Urology·Sandro C EstevesPeter Humaidan
Jul 30, 2018·Journal of Assisted Reproduction and Genetics·C L O'NeillG D Palermo
Feb 11, 2020·Frontiers in Cell and Developmental Biology·Lis C Puga MolinaCelia M Santi
Nov 22, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·G D PalermoZ Rosenwaks
Nov 20, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Timo Fw SoeterikTycho Mtw Lock
Oct 20, 2020·Journal of Assisted Reproduction and Genetics·Ting GengYuanzhen Zhang
Mar 2, 2021·Clinical and Experimental Reproductive Medicine·Alaa El Din-Abdel Aal MoubasherHisham Diab Gaber
Apr 3, 2021·Frontiers in Cell and Developmental Biology·Haibo ZhuQi Zhou
Apr 25, 2021·Biomedical Engineering Online·Anna TargoszGrzegorz Mrugacz
Sep 19, 2021·Environmental Science and Pollution Research International·Temidayo S OmolaoyeStefan S du Plessis

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