To Obtain More With Less: Cytologic Samples With Ancillary Molecular Techniques-The Useful Role of Liquid-Based Cytology

Archives of Pathology & Laboratory Medicine
Maurizio MartiniEsther Diana Rossi

Abstract

- Fine-needle aspiration cytology has been increasingly used as the first tool in the evaluation of several diseases. Although cytology has a relevant role in the discrimination between benign and malignant lesions, conventional slides cannot lead to 100% conclusive results. It was hoped that the introduction of liquid-based cytology (LBC) would improve the efficacy of cytology through standardization, quality improvement, and the possibility of carrying out ancillary techniques on the residual stored material. In recent decades, the application of genomic alterations has been studied on cytologic samples with feasible and reliable results. The molecular analysis offers a powerful aid to define the best clinical or surgical approaches and follow-up for patients. In recent years, the application of different ancillary techniques has been carried out on conventional slides even though LBC represents a useful additional and alternative method for molecular testing. - To demonstrate the relevance of LBC as a valid aid to overcoming the difficulties encountered in the application of ancillary techniques on conventional slides. - We examined and reviewed our experience with the application of ancillary techniques on LBC performed on ...Continue Reading

References

Nov 14, 1997·Diagnostic Cytopathology·D J DabbsG E Radcliffe
Mar 14, 2000·Cytopathology : Official Journal of the British Society for Clinical Cytology·J F NasutiP Gupta
Apr 20, 2000·Cytopathology : Official Journal of the British Society for Clinical Cytology·J P Scurry, M A Duggan
May 10, 2001·The Journal of Clinical Endocrinology and Metabolism·C C CheungS L Asa
May 16, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·H Y DongM B Pitman
Nov 25, 2003·Cytopathology : Official Journal of the British Society for Clinical Cytology·B Cochand-PriolletP-J Guillausseau
Oct 18, 2006·Thyroid : Official Journal of the American Thyroid Association·Guido FaddaFabio Maria Vecchio
Apr 1, 2008·CytoJournal·Husain A SalehHaitham Masri
Aug 8, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Esther Diana RossiGuido Fadda
Apr 9, 2009·Endocrine Pathology·Marina N NikiforovaYuri E Nikiforov
Feb 6, 2010·Cytopathology : Official Journal of the British Society for Clinical Cytology·E D RossiG Fadda
Mar 27, 2010·Cytopathology : Official Journal of the British Society for Clinical Cytology·A SchiettecatteJ de Mey
Oct 21, 2010·The Journal of Molecular Diagnostics : JMD·J Keith KillianPaul S Meltzer
Feb 1, 2011·Thyroid : Official Journal of the American Thyroid Association·Haggi MazehAviram Nissan
Mar 15, 2011·Cancer Cytopathology·Gilda da Cunha SantosNatasha Leighl
Sep 29, 2011·Journal of Clinical Pathology·Umberto MalapelleGiancarlo Troncone
Oct 12, 2011·Acta Cytologica·Guido Fadda, Esther Diana Rossi
Nov 3, 2011·Cancer Cytopathology·Fernando Schmitt, Helena Barroca
Nov 22, 2011·Diagnostic Cytopathology·D L AisnerV M Van Deerlin
Dec 6, 2011·Thyroid : Official Journal of the American Thyroid Association·Rulong ShenHuiling He
Dec 14, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sinchita Roy ChowdhuriArmando C Filie
Feb 18, 2012·Histopathology·Alexander FinkelsteinManju L Prasad
Mar 27, 2012·Endocrine Journal·Homero Gustavo Correia RodriguesLuis Fernando Fernandes Adan
Apr 3, 2012·Journal of Clinical Pathology·Umberto MalapelleGiancarlo Troncone
Sep 19, 2012·Cytopathology : Official Journal of the British Society for Clinical Cytology·M A CatherwoodM Salto-Tellez
Dec 5, 2012·Acta Cytologica·Spasenija Savic, Lukas Bubendorf
May 22, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Spasenija SavicLukas Bubendorf
Aug 28, 2013·The Journal of Clinical Endocrinology and Metabolism·Marina N NikiforovaYuri E Nikiforov
Feb 20, 2014·Virchows Archiv : an International Journal of Pathology·Renu K VirkManju L Prasad

❮ Previous
Next ❯

Citations

Nov 27, 2018·Diagnostic Cytopathology·Eduardo Alcaraz-MateosEnrique Poblet
May 18, 2019·Archives of Pathology & Laboratory Medicine·Kenneth P H Pritzker, Heikki J Nieminen
Jan 12, 2021·Journal of the American Society of Cytopathology : JASC·Jia JiaZhiHui Zhang
Mar 2, 2021·Frontiers in Medicine·Pasquale PisapiaGiancarlo Troncone
Apr 25, 2019·Acta Cytologica·Gordon H YuKaren S Gustafson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.