PMID: 16646401May 2, 2006Paper

To study the expression of dendritic cell phenotypic antigen in cervical lymph nodes in hypopharyngeal carcinoma

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
Xiaoyan LiPin Dong

Abstract

Dendritic cells express many cell phenotypic antigens, they have different special function in the process of antigen present. The purpose of this study was to determine some DC phenotypic antigen in cervical lymphnodes in hypopharyngeal carcinoma and evaluate the relationship between the DC phenotypic antigen expression in hypopharyngeal carcinoma metastasis and prognosis. Envision HIS method was performed to detect the cell surface markers S-100, CD1a and CD83. 144 cervical lymph nodes obtained from 37 cases of hypopharyngeal carcinoma were evaluated. Furthermore, the relationship between CD45RO+ T lymphocytes and dendritic cells was observed. The number of S-100+ DCs, CD1a+ DCs and CD83+ DCs in the cases of lymphnode metastasis were fewer than those in non-lymphnode metastasis. There is a significant metastasis difference in statistics between lymphnode metastasis groupe and non-lymphnode metastasis group. The number of CD83+ DCs located at cancerous nest area were fewer than those at peritumor area in lymphnode metastasis groupe. There is a significant difference in statistics between them. The number of CD83+ DCs in the cases of survival group were more than those in obituary group. CD45RO+ T cells mainly distribute around...Continue Reading

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