To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes

Trends in Cell Biology
Melody M H LiCharles M Rice

Abstract

Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle. We review recent findings implicating a subset of ISGs in translational regulation of viral and host mRNAs. Translation inhibition is mediated either by binding to viral RNA or by disrupting physiological interactions or levels of the translation complex components. In addition, many of these ISGs localize to translationally silent cytoplasmic granules, such as stress granules and processing bodies, and intersect with the microRNA (miRNA)-mediated silencing pathway to regulate translation of cellular mRNAs.

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Citations

Jan 7, 2017·PLoS Pathogens·Melody M H LiMargaret R MacDonald
Jul 22, 2016·Journal of Virology·Irene Lostalé-SeijoJavier Benavente
Jun 28, 2018·Annual Review of Virology·Michiel van GentMichaela U Gack
Mar 21, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Luciano AmarelleJacob I Sznajder
Jul 10, 2019·Annual Review of Virology·Graham D WilliamsStacy M Horner
May 24, 2019·Journal of Virology·Melody M H LiMargaret R MacDonald
Jul 30, 2020·PLoS Pathogens·Margarida Sa RiberoSébastien Nisole
Sep 15, 2020·Seminars in Cell & Developmental Biology·Kate DickerAlfredo Castello
Jan 15, 2021·Developmental and Comparative Immunology·Xue QiaoLinsheng Song
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Apr 28, 2021·BMC Ecology and Evolution·Elena N JuddSara L Sawyer
Aug 10, 2021·Biological Trace Element Research·Fatemeh SadeghsoltaniMostafa Vaghari-Tabari
Oct 27, 2021·The Journal of General Virology·Aminu S Jahun, Ian G Goodfellow
Nov 10, 2017·Cell Host & Microbe·Oliver I Fregoso

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