Tobacco alkaloids and tobacco-specific nitrosamines in dust from homes of smokeless tobacco users, active smokers, and nontobacco users

Chemical Research in Toxicology
Todd WhiteheadP Jacob

Abstract

Smokeless tobacco products, such as moist snuff or chewing tobacco, contain many of the same carcinogens as tobacco smoke; however, the impact on children of indirect exposure to tobacco constituents via parental smokeless tobacco use is unknown. As part of the California Childhood Leukemia Study, dust samples were collected from 6 homes occupied by smokeless tobacco users, 6 homes occupied by active smokers, and 20 tobacco-free homes. To assess children's potential for exposure to tobacco constituents, vacuum-dust concentrations of five tobacco-specific nitrosamines, including N'-nitrosonornicotine [NNN] and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone [NNK], as well as six tobacco alkaloids, including nicotine and myosmine, were quantified by liquid chromatography-tandem mass spectrometry (LC-MS/MS). We used generalized estimating equations derived from a multivariable marginal model to compare levels of tobacco constituents between groups, after adjusting for a history of parental smoking, income, home construction date, and mother's age and race/ethnicity. The ratio of myosmine/nicotine was used as a novel indicator of the source of tobacco contamination, distinguishing between smokeless tobacco products and tobacco smoke...Continue Reading

References

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Jul 26, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Todd P WhiteheadStephen M Rappaport
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Jul 19, 2014·Environment International·Noelia RamírezJacqueline F Hamilton

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Citations

Dec 23, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Vasundhra BahlPrue Talbot
Mar 10, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Ronald AndersonMohammed Tikly
Aug 2, 2015·Current Environmental Health Reports·Jonathan M SametHeather Wipfli
Jul 15, 2017·Journal of Periodontology·Thomas E LallierErin Maturin
Jul 25, 2017·Environmental Science and Pollution Research International·Angelo CecinatoCatia Balducci
Mar 10, 2016·Public Health Reports·Thomas F NorthrupAngela L Stotts
Apr 4, 2021·International Journal of Environmental Research and Public Health·Giovanna L PozuelosPrue Talbot
Apr 26, 2020·Environmental Research·M Velázquez-Gómez, S Lacorte
Dec 22, 2016·Chemical Research in Toxicology·Peyton JacobTodd P Whitehead

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