PMID: 2510603Nov 15, 1989Paper

Tobacco-borne siderophoric activity

Archives of Biochemistry and Biophysics
M W Qian, John W Eaton

Abstract

The proinflammatory and carcinogenic effects of cigarette smoking are well known. Recent evidence indicts iron as a powerful promoter of inflammatory processes and, perhaps not coincidentally, the lungs and alveolar macrophages of smokers contain abnormally large amounts of iron. Furthermore, ferruginous compounds such as asbestos exert a powerful synergy with smoking in the causation of pulmonary neoplasia. Indeed, elements in tobacco smoke and asbestos synergistically damage DNA through reactions mediated by the (probably iron-dependent) formation of hydroxyl radical. These considerations prompted the hypothesis that tobacco smoke might contain substances capable of "delocalizing' iron. We find that one or more substances in organic extracts of smoke and unburned tobacco will transfer iron from an aqueous to an immiscible organic phase. This organic solvation requires the prior reduction of iron which can be effected by elements in smoke extracts. The translation of iron into organic phase is dependent on time and on the concentration of iron within the aqueous phase. Organic condensates of smoke will leach iron from rich forms of asbestos (amosite and crocidolite). Perhaps most importantly, exposure of intact human cells (er...Continue Reading

References

Nov 1, 1977·Analytical Chemistry·I SchmeltzD Hoffmann
Sep 1, 1988·The Journal of Clinical Investigation·I SchraufstätterC G Cochrane
Jun 3, 1988·Science·J A Imlay, S Linn
Oct 1, 1987·Annals of Internal Medicine·C E CrossD Harman
Oct 1, 1987·The American Review of Respiratory Disease·A JanoffZ H Bengali
Feb 24, 1984·Biochimica Et Biophysica Acta·A C Mello Filho, R Meneghini
Feb 15, 1984·The Biochemical Journal·A C Mello FilhoR Meneghini
Dec 1, 1981·Clinical Biochemistry·J D ArtissB Zak

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Citations

Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·R GopalakrishnaU Gundimeda
Dec 20, 2008·The Journal of Biological Chemistry·Xueshan GaoJohn W Eaton
May 3, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Ann E AustRonald F Dodson
May 28, 1993·Annals of the New York Academy of Sciences·P Leanderson
Mar 1, 1993·The Journal of Clinical Investigation·O OlakanmiB E Britigan
Dec 13, 2005·Free Radical Biology & Medicine·Xueshan GaoW Glenn McGregor
Sep 20, 2012·The Biochemical Journal·Lilibeth LancetaJohn W Eaton
Dec 6, 2018·Inhalation Toxicology·Andrew J GhioMichael C Madden
Aug 3, 2017·Environmental Geochemistry and Health·Andrew J Ghio, Michael C Madden
Feb 25, 2020·Free Radical Biology & Medicine·Andrew J GhioMichael C Madden
Apr 9, 2005·The Biochemical Journal·H Lennart PerssonUlf T Brunk

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