PMID: 3286030Jun 1, 1988Paper

Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke

Carcinogenesis
S S Hecht, D Hoffmann

Abstract

Tobacco-specific nitrosamines are a group of carcinogens that are present in tobacco and tobacco smoke. They are formed from nicotine and related tobacco alkaloids. Two of the nicotine-derived nitrosamines, NNK and NNN, are strong carcinogens in laboratory animals. They can induce tumors both locally and systemically. The induction of oral cavity tumors by a mixture of NNK and NNN, and the organospecificity of NNK for the lung are particularly noteworthy. The amounts of NNK and NNN in tobacco and tobacco smoke are high enough that their total estimated doses to long-term snuff-dippers or smokers are similar in magnitude to the total doses required to produce cancer in laboratory animals. These exposures thus represent an unacceptable risk to tobacco consumers, and possibly to non-smokers exposed for years to environmental tobacco smoke. The permission of such high levels of carcinogens in consumer products used by millions of people represents a major legislative failure. Indeed, the levels of tobacco-specific nitrosamines in tobacco are thousands of times higher than the amounts of other nitrosamines in consumer products that are regulated by government authorities. Although the role of tobacco-specific nitrosamines as causati...Continue Reading

Citations

Apr 12, 2002·International Journal of Cancer. Journal International Du Cancer·Kangmin ZhuDouglas R Gnepp
Jan 1, 1993·Journal of Cellular Biochemistry. Supplement·S S HechtF L Chung
Jan 1, 1995·Journal of Cellular Biochemistry. Supplement·K el-BayoumyB S Reddy
Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·N AmmiganS V Bhide
Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·S FischerR Preussmann
Oct 13, 2006·Langenbeck's Archives of Surgery·Stephen S Hecht
Jul 13, 2006·Journal of Cancer Research and Clinical Oncology·Juan ArredondoSergei A Grando
Oct 16, 2012·Environmental Monitoring and Assessment·Tasneem Gul KaziMoina Akhtar Mughal
Aug 1, 2012·Journal of Molecular Neuroscience : MN·Ariane Nunes-AlvesHenning Ulrich
Nov 27, 1995·Biochemical Pharmacology·N R Collazo, L G Sultatos
Nov 1, 1990·Mutation Research·L den EngelseE Scherer
Jan 1, 1992·Pharmacology & Therapeutics·F P Guengerich
Oct 1, 1991·Mutation Research·T JanssonD Jenssen
Jul 1, 1992·Mutation Research·B C Dash, R K Das
Jun 1, 1994·Mutation Research·D M ParisisW G Henderson
Aug 1, 1995·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·O S AltuwairgiH C Doku
Sep 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B G Osterdahl
Jun 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R KumarR Preussmann
Dec 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R K Das, B C Dash
Aug 1, 1989·Cancer Letters·A R Tricker, R Preussmann
Oct 20, 1995·Cancer Letters·S E AtawodiB Spiegelhalder
Sep 1, 1992·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A Castonguay, G Rossignol
Jan 1, 1995·Free Radical Biology & Medicine·J F BilodeauA Castonguay
Apr 1, 1993·European Journal of Cancer. Part B, Oral Oncology·D SaranathM G Deo
Sep 24, 2013·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Harald G EnzmannGary M Williams
Jun 5, 2002·Chemico-biological Interactions·Yih-Shou HsiehChau-Jong Wang
Dec 31, 1997·Mutation Research·B H MathisonM S Bogdanffy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.