Tocilizumab as an Adjuvant Therapy for Hemophagocytic Lymphohistiocytosis Associated With Visceral Leishmaniasis

American Journal of Therapeutics
Raquel Rios-FernándezNorberto Ortego-Centeno

Abstract

Leishmaniasis is important as a cause of hemophagocytic lymphohistiocytosis (HLH) and must be considered and excluded in patients with HLH because it can cause severe or even fatal complications. When HLH is present, there is a deficient downregulation of the immune response, leading to an uncontrolled inflammation. We report a case of visceral leishmaniasis-HLH where the therapy with tocilizumab, targeting interleukin 6, help to regulate the immune response for the infection of Leishmania.

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Citations

Jan 3, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Gabriela Sanchez-PetittoNancy M Hardy
Apr 4, 2021·International Journal of Molecular Sciences·Corrado PelaiaGirolamo Pelaia

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