Tocilizumab for giant cell arteritis with corticosteroid-resistant progressive anterior ischemic optic neuropathy

Joint, Bone, Spine : Revue Du Rhumatisme
Julien VionnetFrançois Spertini

Abstract

Giant cell arteritis is an inflammatory disorder of the medium- and large-size arteries. Permanent visual loss related to arteritic anterior ischemic optic neuropathy is among the most serious complications of this disease and initial treatment usually consists of high dose corticosteroids. There is no consensus in the literature concerning the optimal therapeutic approach in giant cell arteritis patients with corticosteroid-resistant arteritic anterior ischemic optic neuropathy. A 73-year-old Caucasian female with biopsy-proven giant cell arteritis developed an acute visual loss of the right eye due to arteritic anterior ischemic optic neuropathy. Despite 5 daily methylprednisolone pulses, systemic symptoms persisted and rapid involvement of the controlateral eye was documented. Therefore, tocilizumab (humanised monoclonal antibody binding the human interleukin-6 receptor) was introduced as a potential salvage therapy with a swift consecutive resolution of the systemic symptoms and stabilization of the ophthalmic lesions. Although a late effect of steroids pulses cannot be formally ruled out in this dramatic situation, tocilizumab likely offered a decisive effect in preventing bilateral blindness and may have contributed to st...Continue Reading

References

Apr 1, 1993·Ophthalmology·P D AielloG G Hunder
Oct 15, 2003·Arthritis and Rheumatism·Anne ProvenGene G Hunder
Apr 8, 2010·Rheumatology·Bhaskar DasguptaUNKNOWN BSR and BHPR Standards, Guidelines and Audit Working Group
Aug 24, 2012·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Sohan Singh Hayreh, Valérie Biousse
Feb 24, 2015·Seminars in Arthritis and Rheumatism·Javier LoriceraMiguel Á González-Gay
Jun 18, 2015·The New England Journal of Medicine·Valérie Biousse, Nancy J Newman
May 18, 2016·The Journal of Rheumatology·Alexis RégentUNKNOWN French Vasculitis Group, the Groupe Francais pour l’Etude de l’Artérite à Cellules Géantes, and the Club Rhumatismes et Infl
Jul 14, 2016·Circulation. Cardiovascular Imaging·Jessie RisseDenis Wahl

❮ Previous
Next ❯

Citations

Apr 21, 2018·Expert Review of Clinical Immunology·Michael SchirmerCarlo Salvarani
Jan 19, 2018·Angiology·Gianfranco VitielloDaniele Cammelli
Jun 10, 2021·Expert Opinion on Investigational Drugs·Patricia Harkins, Richard Conway

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Optometry : Journal of the American Optometric Association
Michelle Matson, Lane Fujimoto
Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
Zoë R WilliamsDavid A DiLoreto
Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
Nandini SinghIan C Francis
© 2022 Meta ULC. All rights reserved