Tocilizumab for refractory uveitis associated with juvenile idiopathic arthritis: A report of two cases

Journal of Clinical Pharmacy and Therapeutics
Valeria DipasqualeGiovanni Conti

Abstract

Low-grade evidence supports the use of newer biologics for otherwise refractory juvenile idiopathic arthritis (JIA)-associated uveitis, such as tocilizumab. This report details the cases of two adolescents whose severe JIA-associated uveitis was unresponsive to the first-line therapeutic approach. Tocilizumab therapy led to the remission of uveitis after a mean time of 3 weeks, and methotrexate was safely discontinued 1.5 years later. To our knowledge, these are the first reports of successful methotrexate withdrawal during tocilizumab treatment of JIA-associated uveitis. The administration of tocilizumab without methotrexate could be considered in patients with JIA-associated uveitis unresponsive to conventional therapy.

References

Oct 1, 2005·American Journal of Ophthalmology·Douglas A JabsUNKNOWN Standardization of Uveitis Nomenclature (SUN) Working Group
Jun 5, 2012·The Journal of Rheumatology·Christoph TappeinerArnd Heiligenhaus
Dec 21, 2012·The New England Journal of Medicine·Fabrizio De BenedettiUNKNOWN PRCSG
May 20, 2014·Annals of the Rheumatic Diseases·Hermine I BrunnerUNKNOWN Pediatric Rheumatology Collaborative Study Group (PRCSG)
Nov 26, 2015·Survey of Ophthalmology·Madeleine J HawkinsAdam H Ross
Sep 17, 2016·The Journal of Rheumatology·Christoph TappeinerArnd Heiligenhaus

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Citations

Jan 4, 2020·Clinical Rheumatology·Elisabetta MiserocchiRolando Cimaz
Jul 4, 2020·International Ophthalmology·Rohan Bir SinghAniruddha Agarwal

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