Tocilizumab for the treatment of adult patients with severe COVID-19 pneumonia: A single-center cohort study

Journal of Medical Virology
Mario Fernández-RuizJosé María Aguado

Abstract

Coronavirus disease 2019 (COVID-19) can lead to a massive cytokine release. The use of the anti-interleukin-6 receptor monoclonal antibody tocilizumab (TCZ) has been proposed in this hyperinflammatory phase, although supporting evidence is limited. We retrospectively analyzed 88 consecutive patients with COVID-19 pneumonia that received at least one dose of intravenous TCZ in our institution between 16 and 27 March 2020. Clinical status from day 0 (first TCZ dose) through day 14 was assessed by a 6-point ordinal scale. The primary outcome was clinical improvement (hospital discharge and/or a decrease of ≥2 points on the 6-point scale) by day 7. Secondary outcomes included clinical improvement by day 14 and dynamics of vital signs and laboratory values. Rates of clinical improvement by days 7 and 14 were 44.3% (39/88) and 73.9% (65/88). Previous or concomitant receipt of subcutaneous interferon-β (adjusted odds ratio [aOR]: 0.23; 95% confidence interval [CI]: 0.06-0.94; P = .041) and serum lactate dehydrogenase more than 450 U/L at day 0 (aOR: 0.25; 95% CI: 0.06-0.99; P = .048) were negatively associated with clinical improvement by day 7. All-cause mortality was 6.8% (6/88). Body temperature and respiratory and cardiac rates si...Continue Reading

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Citations

Jan 28, 2021·Expert Review of Clinical Pharmacology·Esther Chamorro-de-VegaMaria Sanjurjo
Jan 29, 2021·Expert Opinion on Biological Therapy·Mario Fernández-RuizJosé María Aguado
Nov 20, 2020·Journal of Clinical Laboratory Analysis·Xu YanPing Yang
Feb 13, 2021·Transplantation Proceedings·Anna HardestyDimitrios Farmakiotis
Oct 29, 2020·Current Transplantation Reports·Mario Fernández-Ruiz, José María Aguado
Feb 26, 2021·European Journal of Hospital Pharmacy. Science and Practice·Raquel Moreno DiazMarcela Patricia Homez Guzman
Apr 6, 2021·Clinical Kidney Journal·Néstor ToapantaFrancesc Moreso
Apr 8, 2021·Expert Review of Clinical Immunology·Soheila RezaeiReza Mosaed
Apr 11, 2021·Journal for Immunotherapy of Cancer·Paolo Antonio AsciertoHaiming Wei
Nov 14, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Hernando TrujilloAmado Andrés
Jun 15, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Ahmet Emre EşkazanFehmi Tabak

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