Tocilizumab in the treatment of adult rheumatoid arthritis

Immunotherapy
Raimon SanmartíDolor Soy

Abstract

Rheumatoid arthritis (RA) is the most prevalent immune-mediated chronic rheumatic disease and is associated with joint destruction and disability. Therapeutic strategies, including biological disease-modifying antirheumatic drugs (bDMARDs) have improved the prognosis and quality of life of RA patients. Tocilizumab (TCZ) is a humanized monoclonal antibody against IL-6 receptor licensed in 2009 that has demonstrated clinical efficacy in various adult RA populations. RA management guidelines and recommendations consider TCZ as one of the bDMARDS indicated after methotrexate or other conventional synthetic DMARDs and/or TNF inhibitors failure in adult RA. Of particular interest is the demonstration of its effectiveness in monotherapy in comparison with other bDMARDs. Recent observational studies have shown good results for the safety profile of TCZ with no new alert signals.

References

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Citations

Aug 28, 2020·Scandinavian Journal of Immunology·Bergithe E Oftedal, Anette S B Wolff
Aug 25, 2020·Current Pharmacology Reports·Linzi FanChunjuan Yang
Mar 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Wei ZhangXiaoyi Jia
Nov 17, 2020·International Reviews of Immunology·Rodrigo Cerqueira BorgesSergio Marques Borghi
Oct 30, 2020·Risk Management and Healthcare Policy·Azadeh Teimury, Elahe Mahmoodi Khaledi
Oct 15, 2020·European Journal of Pharmacology·Livia L CamargoSoraia K P Costa

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