Tocopheryl succinate-based lipid nanospheres for paclitaxel delivery: preparation, characters, and in vitro release kinetics

Drug Delivery
Kai ShiFude Cui

Abstract

Despite its strong anti-tumor activity against human cancers, paclitaxel (Taxol®) suffers limited clinical applications due to the low aqueous solubility and lack of appropriate delivery vehicles. In an attempt to develop an alternative formulation of paclitaxel suitable for parenteral administration, paclitaxel-loaded lipid nanospheres were constructed as colloidal carrier system for controlled drug delivery. Alpha-tocopheryl succinate (α-TOS), a semi-synthetic vitamin E analog, was employed as a new physiological acceptable lipid material to prepare nanoparticulates. A novel bottom-up process was performed by a modified spontaneous emulsification solvent-diffusion method, which is suitable for large industrial scale production. The influence of key parameters such as temperature and surfactant concentration on the size and uniformity of the distribution of nanospheres were investigated. Spherical particles with ∼100 nm of mean diameter and 90% of drug entrapment efficiency were obtained under optimal conditions. Physicochemical characterization of the particles reveals a molecular dispersion of paclitaxel in the lipidic matrix. The in vitro release behavior of paclitaxel from the developed nanospheres was characterized by an ...Continue Reading

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Citations

Apr 14, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kimberley ElbrinkFilip Kiekens
Jan 1, 2022·Photochemistry and Photobiology·Kazi Md Mahabubur RahmanYoungjae You

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