Mar 1, 2000

Toenail selenium and breast cancer-a case-control study in Finland

European Journal of Clinical Nutrition
S MännistöP Pietinen

Abstract

Low levels of selenium have been associated with a higher risk of cardiovascular diseases and cancer in humans. Since 1984, selenium supplementation through fertilizers has been employed in Finland to increase the very low concentration of selenium in the nation's food supply. As a result, the selenium concentration of Finnish foods became one of the highest in Europe. A decade after selenium supplementation began, the association between toenail selenium and the risk of breast cancer was examined. Case-control study. Eastern Finland. 289 pre- and postmenopausal breast cancer cases and 433 community controls. The diagnosis was unknown at the time the toenail samples were collected. The mean toenail selenium concentration was 0.80 mg/kg in premenopausal cases and 0.84 mg/kg in premenopausal controls: and 0. 77 mg/kg in postmenopausal cases and 0.80 mg/kg in postmenopausal controls. The odds ratio (OR) comparing the highest with the lowest quintiles of toenail selenium concentration was 1.1 (95% CI 0.4-3.2) in premenopausal women and 0.7 (95% CI 0.3-1.5) in postmenopausal women. The intake of retinol, beta-carotene, vitamin E and vitamin C did not change the association between toenail selenium and breast cancer. A decade after s...Continue Reading

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Mentioned in this Paper

Vitamin A
Entire Nail of Toe
Selenium
Premenopausal Symptoms
Clinical Nutrition
Vitamin E Assay
Senility
Odds Ratio
Etiology
Cardiovascular Diseases

About this Paper

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