TOF-SIMS: accurate mass scale calibration

Journal of the American Society for Mass Spectrometry
Felicia M GreenMartin P Seah

Abstract

A study is presented of the factors affecting the calibration of the mass scale in time-of-flight secondary ion mass spectrometry (TOF-SIMS). At the present time, TOF-SIMS analysts using local calibration procedures achieve a rather poor relative mass accuracy of only 150 ppm for large molecules (647 u) whereas for smaller fragments of <200 u this figure only improves to 60 ppm. The instrumental stability is 1 ppm and better than 10 ppm is necessary for unique identification of species. The above experimental uncertainty can lead to unnecessary confusion where peaks are wrongly identified or peaks are ambiguously assigned. Here we study, in detail, the instrumental parameters of a popular single stage reflection TOF-SIMS instrument with ion trajectory calculations using SIMION. The effect of the ion kinetic energy, emission angle, and other instrumental operating parameters on the measured peak position are determined. This shows clearly why molecular and atomic ions have different relative peak positions and the need for an aperture to restrict ions at large emission angles. These data provide the basis for a coherent procedure for optimizing the settings for accurate mass calibration and rules by which calibrations for inorga...Continue Reading

References

Oct 8, 2003·Journal of the American Society for Mass Spectrometry·Anthony W T Bristow, Kenneth S Webb

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Citations

Sep 29, 2011·Journal of the American Society for Mass Spectrometry·Joanna L S LeeIan W Fletcher
Apr 8, 2016·Integrative Biology : Quantitative Biosciences From Nano to Macro·Xin HuaXiao-Ying Yu
Feb 25, 2015·Biointerphases·Valentina SpampinatoSilvia Giordani
May 18, 2016·Analytical Chemistry·Gregory L FisherRon M A Heeren
Oct 7, 2016·Analytical Chemistry·Yuanzhao DingXiao-Ying Yu
Jun 10, 2017·Physical Chemistry Chemical Physics : PCCP·Xiao SuiXiao-Ying Yu
Dec 10, 2016·Rapid Communications in Mass Spectrometry : RCM·Soheila Naderi-GoharHeng-Yong Nie
Jan 3, 2007·Journal of Mass Spectrometry : JMS
Jan 23, 2009·Rapid Communications in Mass Spectrometry : RCM·Martin P SeahFelicia M Green
Mar 9, 2019·Annual Review of Analytical Chemistry·Ian S GilmoreCornelius L Pieterse
Feb 12, 2021·Science Advances·Shambavi GaneshAhmet F Coskun
Feb 4, 2010·Analytical Chemistry·Santiago Solé-DomènechPeter Sjövall
Jan 10, 2012·Analytical Chemistry·Steven J Pachuta, Paul R Vlasak
Oct 26, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Ricardo TejeroIlya Reviakine
Nov 18, 2014·ACS Applied Materials & Interfaces·Kjell W SchroderKeith J Stevenson

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