Together We Are Stronger: Protein Clustering at the Nanoscale

ACS Nano
Yves F Dufrêne

Abstract

Cell surface proteins are known to assemble into nano- and microscale domains in order to govern biological processes, including cell adhesion, endocytosis, and immune responses. The small size and ephemerality of these structures have made their direct observation and functional analysis challenging. In this Perspective, I discuss recent progress made in applying nanotechniques to study protein clustering, emphasizing the use of state-of-the-art single-molecule atomic force microscopy, as reported by Strasser et al. in this issue of ACS Nano.

References

Jun 24, 2005·Nature Methods·Vincent DupresYves F Dufrêne
Apr 22, 2006·Nature Methods·Peter Hinterdorfer, Yves F Dufrêne
Jan 1, 2009·Nature Methods·Stefan W Hell
Jan 2, 2010·Science·Daniel Lingwood, Kai Simons
Nov 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·David AlsteensYves F Dufrêne
Oct 25, 2011·Nature·Geert van den BogaartReinhard Jahn
Jul 10, 2012·Nature Nanotechnology·Ignacio CasusoSimon Scheuring
Aug 30, 2013·Nature Methods·Yves F DufrêneDaniel J Müller
Jan 31, 2014·Chemical Reviews·Toshio AndoSimon Scheuring
Jan 31, 2015·Nature Communications·Dragomir MilovanovicReinhard Jahn
Oct 27, 2016·Nature Microbiology·Jie Xiao, Yves F Dufrêne
Apr 7, 2017·Nature Nanotechnology·Yves F DufrêneDaniel J Müller

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Citations

Jan 21, 2021·Journal of Bacteriology·Albertus ViljoenYves F Dufrêne

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