Tolerability and efficacy of deferasirox in patients with transfusional iron overload: results from a German 2-year non-interventional study

Journal of Cancer Research and Clinical Oncology
Florian NolteWolf-Karsten Hofmann

Abstract

Iron overload (IOL) due to repetitive transfusions of packed red blood cells (pRBC) has a major impact on morbidity and mortality in patients with inherited bone marrow failure syndromes and hemoglobinopathies such as thalassemia and sickle cell disease. However, whether IOL influences the outcome of elderly patients with myeloid malignancies is not yet clear. Moreover, clinical trials have reported high drop-out rates during treatment with the oral iron chelator deferasirox (DFX). Here we report the results of a 2-year prospective observational study that aimed at describing the routine use of DFX in patients with hematological malignancies with regard to safety, efficacy and handling of the drug in a routine setting. A total of 406 patients were included. 58% of the patients were male. Most of the patients had myelodysplastic syndromes (MDS) (68%) and myeloproliferative neoplasms (MPN) (14%). Median time from first transfusion to study enrollment was 1.1 years (0-25.5 years) and most patients were chelation naive (91%) at enrollment. With regard to transfusion burden, most of the patients were moderately or mildly transfusion-dependent with 53% receiving 2-4 and 27% receiving less than 2 units of pRBC per month. Serum ferriti...Continue Reading

References

Oct 13, 2010·Annals of Hematology·Norbert Gattermann, Eliezer A Rachmilewitz
May 2, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alan F ListEmmanuel Besa

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Citations

Apr 21, 2021·Expert Opinion on Drug Safety·Laura GrechJoseph Borg

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