Tolerability and pharmacokinetic profile of a novel benzene-poly-carboxylic acids complex with cis-diammineplatinum (II) dichloride in dogs with malignant mammary tumours

Veterinary and Comparative Oncology
V M KristiansenStig Larsen

Abstract

The pharmacokinetic profile, tolerability and efficacy of benzene-poly-carboxylic acids complex with cis-diammineplatinum (II) dichloride (BP-C1) were studied in dogs with mammary cancer. A three-level response surface pathway designed trial was performed on seven dogs. At each level BP-C1 was administered subcutaneously daily for 7 days followed by a 7-day rest period in a dose escalating manner. Adverse events according to VCOG-CTCAE, performance status and tumour progression were recorded. The pharmacokinetic profile followed a two-compartment model with rapid absorption, short distribution, and a slow elimination phase. The overall elimination half-life was 125 h. The maximum tolerated dose of BP-C1 was estimated to be above 0.46 mg kg(-1) . A significant reduction in VCOG-CTCAE toxicity which correlated negatively with increasing dose was found. The dogs' general performance status remained unchanged. No decrease in total tumour burden was found, although temporary tumour reduction was seen in some target tumours.

References

Jul 1, 1979·The Journal of Small Animal Practice·W Misdorp, A A Hart
Jul 1, 1991·Scandinavian Journal of Gastroenterology·S LarsenM Osnes
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·L Sandvik
Aug 1, 1987·European Journal of Cancer & Clinical Oncology·P LelieveldD van Velzen
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·H PetersenP M Kleveland
May 1, 1985·Scandinavian Journal of Gastroenterology·S LarsenL Sandvik
Jan 1, 1985·Scandinavian Journal of Gastroenterology·P M KlevelandH Petersen
Apr 24, 2001·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·M KarayannopoulouA Dessiris
Mar 14, 2002·Biometrics·Mario Stylianou, Nancy Flournoy
Sep 14, 2002·Statistics in Medicine·William F Rosenberger, Linda M Haines
Feb 19, 2003·Statistics in Medicine·Mario StylianouNancy Flournoy
Jan 18, 2008·Veterinary Surgery : VS·Nina StratmannAxel Wehrend
Jun 20, 2008·Journal of Veterinary Internal Medicine·D F MerloV Bocchini
Jan 31, 2009·Veterinary and Comparative Oncology·L MarconatoE Zini
Jan 27, 2011·Veterinary Pathology·M GoldschmidtV Zappulli
Mar 26, 2014·BMC Pharmacology & Toxicology·Sagita DewiStig Larsen

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