Abstract
To assess the tolerability and efficacy of amodiaquine (AQ)+sulphadoxine-pyrimethamine (SP), the first-line malaria treatment in Rwanda. Randomized, double-blind trial in 2003 in Kigali town. A total of 351 adult patients with uncomplicated Plasmodium falciparum malaria were randomly allocated to one of the following treatments: AQ+SP, AQ or SP. We followed patients until day 14 after treatment and recorded adverse events (AEs) and clinical and parasitological outcomes. One hundred and eighteen patients reported at least one AE: 40% in the AQ, 39% in the AQ+SP and 21% in the SP groups. The AE was classified as possibly related to the antimalarial treatment for 86 patients. The Risk Ratio for at least one AE after treatment was significantly and about fourfold higher in patients receiving AQ or AQ+SP than in patients receiving SP. Pruritus and fatigue were significantly more frequent in patients treated with AQ or AQ+SP than in those receiving SP. Severe AEs, such as fatigue, nausea, dizziness and vomiting, were observed in four patients treated with AQ, in 10 treated with AQ+SP and in one patient treated with SP. Amodiaquine+SP is not well tolerated and a substantial proportion of patients experienced pruritus and fatigue, thus...Continue Reading
References
Apr 1, 1992·Biochemical Pharmacology·A C HarrisonB K Park
Feb 1, 1990·Journal of the Royal Society of Medicine·P A Phillips-Howard, L J West
Jan 1, 1990·International Archives of Allergy and Applied Immunology·J B ClarkeB K Park
Feb 22, 1986·Lancet·C S HattonP Winstanley
Mar 15, 1986·British Medical Journal·K A NeftelJ Fehr
Mar 1, 1987·The American Journal of Medicine·M L EstesN B Ratliff
Nov 2, 1996·Lancet·P OlliaroP Brasseur
Aug 15, 2001·Lancet·S G StaedkeP J Rosenthal
Oct 16, 2004·Tropical Medicine & International Health : TM & IH·Claude E RwagacondoUmberto D'Alessandro
Feb 26, 2005·Tropical Medicine & International Health : TM & IH·Abraham R OduroJoseph Amankwa
Jul 22, 2005·PLoS Medicine·Adoke YekaGrant Dorsey
Citations
Jun 13, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Corine KaremaUmberto D'Alessandro
Nov 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Issaka ZongoJean Bosco Ouédraogo
Aug 30, 2008·The Journal of Infectious Diseases·Christine Alexandra ClerkDaniel Chandramohan
Dec 19, 2012·Malaria Journal·George O AdjeiBamenla Q Goka
Jun 13, 2008·Malaria Journal·Catherine Maiteki-SebuguziSarah G Staedke
Jun 13, 2008·Malaria Journal·Sarah G StaedkeAmbrose O Talisuna
Apr 7, 2010·PloS One·Frank O OdhiamboRobert D Newman
Oct 27, 2010·PloS One·Joaniter NankabirwaSarah G Staedke
Aug 12, 2014·Malaria Journal·Abel NhamaEusebio Macete
Oct 19, 2006·Lancet·Umberto D'Alessandro, Feiko O ter Kuile
Dec 11, 2007·Médecine et maladies infectieuses·M NzayirambahoG Potel
May 26, 2009·Expert Opinion on Pharmacotherapy·Umberto D'Alessandro
Mar 31, 2017·Pharmacology Research & Perspectives·Peter U BassiAmbrose O Isah
Oct 9, 2020·Malaria Journal·Corine KaremaAllison Tatarsky