Tolerability of amodiaquine and sulphadoxine-pyrimethamine, alone or in combination for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan adults

Tropical Medicine & International Health : TM & IH
Caterina I FanelloUmberto D'Alessandro

Abstract

To assess the tolerability and efficacy of amodiaquine (AQ)+sulphadoxine-pyrimethamine (SP), the first-line malaria treatment in Rwanda. Randomized, double-blind trial in 2003 in Kigali town. A total of 351 adult patients with uncomplicated Plasmodium falciparum malaria were randomly allocated to one of the following treatments: AQ+SP, AQ or SP. We followed patients until day 14 after treatment and recorded adverse events (AEs) and clinical and parasitological outcomes. One hundred and eighteen patients reported at least one AE: 40% in the AQ, 39% in the AQ+SP and 21% in the SP groups. The AE was classified as possibly related to the antimalarial treatment for 86 patients. The Risk Ratio for at least one AE after treatment was significantly and about fourfold higher in patients receiving AQ or AQ+SP than in patients receiving SP. Pruritus and fatigue were significantly more frequent in patients treated with AQ or AQ+SP than in those receiving SP. Severe AEs, such as fatigue, nausea, dizziness and vomiting, were observed in four patients treated with AQ, in 10 treated with AQ+SP and in one patient treated with SP. Amodiaquine+SP is not well tolerated and a substantial proportion of patients experienced pruritus and fatigue, thus...Continue Reading

References

Apr 1, 1992·Biochemical Pharmacology·A C HarrisonB K Park
Feb 1, 1990·Journal of the Royal Society of Medicine·P A Phillips-Howard, L J West
Jan 1, 1990·International Archives of Allergy and Applied Immunology·J B ClarkeB K Park
Mar 15, 1986·British Medical Journal·K A NeftelJ Fehr
Mar 1, 1987·The American Journal of Medicine·M L EstesN B Ratliff
Oct 16, 2004·Tropical Medicine & International Health : TM & IH·Claude E RwagacondoUmberto D'Alessandro
Feb 26, 2005·Tropical Medicine & International Health : TM & IH·Abraham R OduroJoseph Amankwa

❮ Previous
Next ❯

Citations

Jun 13, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Corine KaremaUmberto D'Alessandro
Nov 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Issaka ZongoJean Bosco Ouédraogo
Jun 13, 2008·Malaria Journal·Sarah G StaedkeAmbrose O Talisuna
Oct 19, 2006·Lancet·Umberto D'Alessandro, Feiko O ter Kuile
May 26, 2009·Expert Opinion on Pharmacotherapy·Umberto D'Alessandro

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.