Tolerability of Cefazolin and Ceftibuten in Patients with IgE-Mediated Aminopenicillin Allergy.

The Journal of Allergy and Clinical Immunology. in Practice
Antonino RomanoFrancesco Gaeta

Abstract

Side-chain similarities or identities constitute the predominant factor for cross-reactivity between penicillins and cephalosporins, whereas differences in the side-chain structure seem to account for the absence of such cross-reactivity. We sought to assess the cross-reactivity between penicillins and 2 cephalosporins (ie, cefazolin and ceftibuten) that have side chains different from those of penicillins, as well as to evaluate the possibility of using these cephalosporins in penicillin-allergic subjects. We conducted a prospective study of 131 consecutive subjects who had suffered 170 immediate reactions (mostly anaphylaxis) to penicillins and had positive skin test results to at least 1 penicillin reagent. All patients underwent skin tests with cefazolin and ceftibuten. Patients with negative results were challenged with them. One participant had positive skin test results to cefazolin and ceftibuten, as well as to all other reagents tested, including aztreonam and carbapenems. All 129 subjects who underwent challenges with cefazolin and ceftibuten tolerated them. One subject refused cephalosporin challenges. Subjects with an IgE-mediated hypersensitivity to penicillins could be treated with cephalosporins such as cefazolin...Continue Reading

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Citations

Nov 18, 2020·Deutsche medizinische Wochenschrift·Annette Hennigs, Johannes Jochum
Dec 10, 2020·Clinical and Translational Allergy·Gador BogasMaría Isabel Montañez
Jan 28, 2021·Journal of Asthma and Allergy·Cristiano CarusoAntonino Romano
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Dec 1, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Antonino RomanoFrancesco Gaeta
Mar 27, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Karen M AnsteyIris M Otani
May 13, 2021·Surgical Endoscopy·Bradley S KushnerShaina R Eckhouse
Jun 20, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Vito SabatoAntonino Romano
Jun 3, 2021·Current Opinion in Allergy and Clinical Immunology·Javier FernandezNatalia Blanca-Lopez
Aug 17, 2021·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Mary Elizabeth SextonZanthia Wiley

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