Tolerability to dogfish in children with fish allergy

Allergologia et immunopathologia
S Calderon-RodriguezC Muñoz

Abstract

Fish is a potent food allergen. The aim of this work is to demonstrate that dogfish, a small shark, has low allergenicity in both its clinical tolerance as well as its molecular structure. We present a study of 34 paediatric patients with IgE-mediated immediate reactions after eating fish. The diagnosis of several fish allergies was demonstrated by skin prick techniques and determination of specific IgE, in all the cases excluding sensitisation to Anisakis simplex. Open oral challenge test was checked with dogfish. Analysis was by SDS-PAGE of dogfish and other fish (megrim, shark, hake, sole, cod, anchovy and tuna) and Western-blot with "pool" of patients polysensitised sera against extracts of dogfish and other fish, and ELISA - inhibition with the "pool" sera. The prick-prick with raw dogfish was slightly positive in six patients, however cooked was negative in 34 cases. The specific IgE showed in the 34 cases class ≥2 for megrim, hake, sole, cod and anchovy, class 0 for tuna in 26 patients, class 0 for emperor in 18 patients and class 0 to Anisakis simplex in all cases. The IgE binding capacity for proteins of allergenic extracts of tested fish revealed, in immunoblotting, the absence of IgE-mediated recognition abstract dog...Continue Reading

References

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Citations

Jan 25, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J N StephenA L Lopata
Aug 24, 2017·Current Allergy and Asthma Reports·Christiane HilgerAnnette Kuehn
Jan 13, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Amanda L CoxScott H Sicherer
Jun 23, 2021·Food Chemistry·Raquel Pérez-TavarezMaría Gasset

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