Tolerance and cross-tolerance to the effects of amphetamine, methamphetamine and fenfluramine on milk consumption in the rat.

Pharmacology, Biochemistry, and Behavior
D KandelM W Fischman

Abstract

It has been reported that rats develop tolerance to the milk intake suppressant effects of d-amphetamine, d-methamphetamine, and d, l-fenfluramine. However, it has been hypothesized that the mechanism of action of fenfluramine is different from that of the other two drugs. In the present experiment, rats were given one of these 3 phenylethylamine derivatives each day until tolerance developed to the suppression of milk intake. A second of these drug s was then substituted and milk intake measured. There was cross-tolerance to the drug-induced suppression between d-amphetamine and d-methamphetamine, but not between d-amphetamine and d,l-fenfluramine. The lack of cross tolerance suggests a different mechanism of action for these drugs.

References

Jan 1, 1973·The Journal of Pharmacy and Pharmacology·S Jespersen, J Scheel-Krüger
Aug 1, 1971·Toxicology and Applied Pharmacology·D L GilbertK D Courtney
Aug 1, 1971·Physiology & Behavior·P L Carlton, D L Wolgin

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Citations

May 1, 1980·Pharmacology, Biochemistry, and Behavior·W L WoolvertonR L Balster
Dec 1, 1980·Pharmacology, Biochemistry, and Behavior·W L WoolvertonC E Johanson
Jan 1, 1985·Pharmacology, Biochemistry, and Behavior·R N Hunsinger, M C Wilson
May 1, 1989·Pharmacology, Biochemistry, and Behavior·M B Nichols, R P Maickel
Jan 1, 1987·Pharmacology & Therapeutics·M F Sugrue
Jan 1, 1986·Progress in Neurobiology·N E Rowland, J Carlton
Sep 24, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Kate McDonnell-Dowling, John P Kelly
Jun 30, 1985·Toxicology and Applied Pharmacology·R N HunsingerM C Wilson

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