Tolerance and efficacy of mefloquine as the first line treatment of uncomplicated P. falciparum malaria in children

Pathologie-biologie
P ValeyreN Parez

Abstract

Given the national therapeutic guidelines in France, halofantrine represents the first line treatment of uncomplicated Plasmodium falciparum (P. falciparum) malaria in children. But several disadvantages exist using halofantrine in paediatrics. The primary objective of this study is to evaluate the tolerance and the efficacy of mefloquine as the first line treatment of uncomplicated P. falciparum malaria in a paediatric emergency department. The secondary objective of the study is to evaluate whether symptomatic measures may improve the gastrointestinal tolerance of mefloquine. This retrospective observational cohort study includes all the patients who have been treated for acute uncomplicated P. falciparum malaria in the paediatric emergency department of the Hospital Trousseau (Paris, France) in 2003. First line treatment was mefloquine in 35 children. Early vomiting occurred in 22 (63%) cases. All children responded to mefloquine therapy except two children who had persistent vomiting early after mefloquine therapy and required intravenous quinine. Those two children had initial vomiting. Light meal and metopimazine prophylaxis did not precede mefloquine intake in those two children. This study suggests that mefloquine treat...Continue Reading

References

Nov 1, 1989·The Pediatric Infectious Disease Journal·A Lynk, R Gold
May 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·A Sowunmi, A M Oduola
Jul 13, 2004·The Pediatric Infectious Disease Journal·François DubosDominique Gendrel

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Citations

May 21, 2011·The Pediatric Infectious Disease Journal·Philippe MinodierStephane Ranque
Feb 1, 2011·Médecine et maladies infectieuses·L ElmansoufUNKNOWN Réseau interhospitalier d'évaluation des pratiques médicales dans les affections courantes de l'enfant

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