Tolerance and future directions for composite tissue allograft transplants: part II

Plastic and Reconstructive Surgery
Maria Z Siemionow, A Klimczak

Abstract

After studying this article, the participant should be able to: 1. Discuss the definition and basic aspects of tolerance as applied to clinical practice. 2. Understand the role of donor bone marrow cells for tolerance induction in composite tissue allograft. 3. Understand the role of passenger leukocytes in allograft acceptance and rejection. 4. Understand the tolerogenic role of dendritic cells and regulatory cells in composite tissue allograft transplants. 5. Understand modern approaches to transplantation tolerance and their applicability to composite tissue allograft transplants. The introduction of composite tissue allograft transplants into clinical practice has become reality because of well-established microsurgical techniques. However, the success of composite tissue allograft transplants is still dependent on chronic immunosuppression. Clinically applicable protocols for tolerance induction in composite tissue allograft would eliminate the need for lifelong immunosuppression. The major goal of transplantation immunology is to develop immunologic nonresponsiveness (tolerance) to allograft transplants and long-term drug-free survival. A number of protocols have been designed to develop tolerance in experimental systems;...Continue Reading

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May 13, 2014·Transplantation Proceedings·K M Lee, S-C Eun
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