Tolerance and lymphoid organ structure and function.

Frontiers in Immunology
Bryna E BurrellJonathan S Bromberg

Abstract

This issue of Frontiers in Immunologic Tolerance explores barriers to tolerance from a variety of views of cells, molecules, and processes of the immune system. Our laboratory has spent over a decade focused on the migration of the cells of the immune system, and dissecting the signals that determine how and where effector and suppressive regulatory T cells traffic from one site to another in order to reject or protect allografts. These studies have led us to a greater appreciation of the anatomic structure of the immune system, and the realization that the path taken by lymphocytes during the course of the immune response to implanted organs determines the final outcome. In particular, the structures, microanatomic domains, and the cells and molecules that lymphocytes encounter during their transit through blood, tissues, lymphatics, and secondary lymphoid organs are powerful determinants for whether tolerance is achieved. Thus, the understanding of complex cellular and molecular processes of tolerance will not come from "96-well plate immunology," but from an integrated understanding of the temporal and spatial changes that occur during the response to the allograft. The study of the precise positioning and movement of cells ...Continue Reading

Citations

Apr 4, 2014·Cancer Immunology, Immunotherapy : CII·Karīna SiliņaAija Linē
May 15, 2012·Trends in Immunology·Honsoul KimGou Young Koh
Jul 11, 2013·Current Opinion in Organ Transplantation·C Colin BrinkmanJonathan S Bromberg
Apr 3, 2014·The Journal of Clinical Investigation·Kristi J WarrenBryna E Burrell
Oct 3, 2018·The Journal of Clinical Investigation·Baharak BahmaniReza Abdi
Dec 18, 2019·International Journal of Pharmaceutics·Cheng DengMingxing Xie

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