Tolerance and sensitization to the behavioral effects of cocaine in rats: relationship to benzodiazepine receptors

Pharmacology, Biochemistry, and Behavior
N E GoedersG F Guerin

Abstract

Tolerance and sensitization to the behavioral effects of cocaine were investigated in rats responding under a fixed-consecutive-number eight schedule of food reinforcement. The development of tolerance or sensitization was induced by delivering the drug either immediately before or after each behavioral session during chronic administration. Chronic cocaine administered before each session resulted in tolerance, as indicated by the shift to the right in the cocaine dose response curve. This tolerance was more likely to develop in the presence of an external discriminative stimulus. On the other hand, when cocaine was delivered after each session, the injections did not disrupt responding and sensitization or increased sensitivity rather than tolerance developed. This sensitization was more likely to occur when the external discriminative stimulus was not present. These data suggest that either tolerance or sensitization to the behavioral effects of cocaine can occur following the same number of chronic injections, with the effect dependent on the context under which the drug is delivered. Significant differences in benzodiazepine receptor binding measured autoradiographically using [3H]flumazenil were observed between rats that...Continue Reading

References

Apr 29, 1977·Psychopharmacology·L ShusterA Bates
Mar 15, 1977·Life Sciences·M M Kilbey, E H Ellinwood
Dec 1, 1978·Neuropharmacology·L R Nelson, G Ellison
Sep 1, 1978·Pharmacology, Biochemistry, and Behavior·W L WoolvertonC R Schuster
Mar 1, 1975·The American Journal of Psychiatry·R M Post
Aug 1, 1989·Pharmacology, Biochemistry, and Behavior·N E GoedersK H McAllister
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·K F Schama, M N Branch
Jul 1, 1988·Pharmacology, Biochemistry, and Behavior·M N Branch, G M Sizemore
May 5, 1988·The New England Journal of Medicine·F H Gawin, E H Ellinwood
Nov 1, 1987·Pharmacology, Biochemistry, and Behavior·D M WoodM W Emmett-Oglesby
May 1, 1986·The American Journal of Psychiatry·T A Aronson, T J Craig
Mar 1, 1974·Pharmacology, Biochemistry, and Behavior·D S Segal, A J Mandell
May 1, 1969·European Journal of Pharmacology·L Magos
Jan 1, 1966·Psychopharmacologia·C R SchusterJ H Woods
Jan 1, 1984·Journal of Receptor Research·J M Palacios
Jul 1, 1982·Journal of Neuroscience Methods·J R UnnerstallJ M Palacios
Jan 1, 1981·Psychopharmacology·V G LatiesD C Rees
May 1, 1982·Pharmacology, Biochemistry, and Behavior·M N Branch, M E Dearing
Jun 1, 1980·American Heart Journal·T H Self, R E Vanderbush
Feb 1, 1993·Pharmacology, Biochemistry, and Behavior·N E GoedersG F Guerin

❮ Previous
Next ❯

Citations

Jun 17, 1999·Pharmacology, Biochemistry, and Behavior·A L Riley, G R Simpson
Jan 8, 1999·Peptides·G A OlsonA J Kastin
May 1, 1997·Psychoneuroendocrinology·N E Goeders
Jan 4, 2003·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Gopakumar P. Panikkar
Jun 3, 2014·Brain Research·Glenn F GuerinNicholas E Goeders
Mar 29, 2006·Biological Psychiatry·Eric J Nestler, William A Carlezon
Apr 25, 2000·Neuron·J D Berke, S E Hyman
Jun 25, 2014·Behavioural Brain Research·Christopher D SchmoutzNicholas E Goeders
Oct 26, 1999·Endocrine Reviews·E A Nillni, K A Sevarino
Feb 1, 2011·Journal of the Experimental Analysis of Behavior·Jonathan W Pinkston, Marc N Branch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.