PMID: 15374134Jan 1, 1997Paper

Tolerance and side-effects of paroxetine in elderly depressed patients

Archives of Gerontology and Geriatrics
K Ghose

Abstract

Paroxetine, a selective serotonin reuptake inhibitor (SSRI) antidepressant, is considered to have fewer side-effects than a typical tricyclic antidepressant. As the elderly frequently suffer from adverse effects of psychotropic drugs, safeties and tolerance of paroxetine and their relationship with dose were studied in a double-blind study. Sixteen nondashhospitalised depressed patients, aged 72-86 years, were recruited but 12 patients completed the study. Patients were randomly selected to receive either 15 mg or 30 mg paroxetine daily for 42 days in a double-blind study. A trained nurse made weekly home visits to monitor their medication and general conditions. Patients were assessed at the hospital on days 1, 7, 14, 28 and 42. There were four drop-outs during the first week of study due to lack of motivation, skin rash and upper gastrointestinal symptoms (n=2). Plasma levels of paroxetine showed a dose-related increase in concentrations and indicated a good compliance. At the dosages used, no changes in blood pressure, heart rate, salivary volume, visual choice reaction time, critical flicker fusion threshold and short-term memory were observed in these patients. However, there was a significant improvement in their subjecti...Continue Reading

References

Jan 1, 1989·Acta Psychiatrica Scandinavica. Supplementum·G F HebenstreitG C Dunbar
Jan 1, 1989·Acta Psychiatrica Scandinavica. Supplementum·K Ghose
Mar 1, 1985·Acta Psychiatrica Scandinavica·A L LaursenP le Fèvre Honoré
May 1, 1985·British Journal of Clinical Pharmacology·S M HassanP Turner
Apr 1, 1987·Archives of Gerontology and Geriatrics·K Ghose
Mar 21, 1981·British Medical Journal·M D Rawlins
Apr 4, 1981·British Medical Journal·J Ross
Apr 1, 1994·Drugs & Aging·K Ghose
Dec 1, 1995·Molecular Medicine Today·P M Rowe

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Citations

Apr 10, 2002·Pharmacotherapy·Tracie J SannicandroJohn S Markowitz
Nov 6, 2008·Expert Opinion on Drug Safety·David M MarksChi-Un Pae
Jul 5, 2005·Expert Opinion on Investigational Drugs·S Bartlett, C Ballard
Jun 10, 2009·Expert Opinion on Drug Safety·Chi-Un Pae
Jul 26, 2012·Cambridge Quarterly of Healthcare Ethics : CQ : the International Journal of Healthcare Ethics Committees·Jacob M Appel

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