PMID: 9634646Jun 23, 1998Paper

Tolerance develops to the antinociceptive and motor impairing effects of ACEA-1416, a NMDA receptor antagonist, in the formalin and rotarod test in mice

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
K Lutfy, E Weber

Abstract

Antinociception, disturbances of motor coordination and development of tolerance to these effects were examined following acute and chronic administration of ACEA-1416, a NMDA receptor/glycine site antagonist, in Swiss Webster mice using the formalin and rotarod tests. In the formalin test, mice were injected with either the vehicle (Tris, 0.05 M) or ACEA-1416 (1-10 mg kg-1). Fifteen or 60 min later, mice were injected with formalin and observed for nociceptive responses (licking and/or biting of the injected paw). In the vehicle-treated control mice a biphasic nociceptive response was observed at 0-5 min (early phase) and from 15 to 50 min (late phase) after formalin injections. ACEA-1416 showed a dose-dependent attenuation of the nociceptive responses in both phases of the formalin test. In the rotarod test, mice were injected with ACEA-1416, placed on a rotating bar at 6 rpm for 2 min and examined for motor impairments. ACEA-1416 produced disturbances of motor coordination in a dose-dependent manner. For tolerance studies, mice were injected once daily with either the vehicle or ACEA-1416 (30 mg kg-1) and tested for antinociception and motor impairment on day 5, 10 and 20. A time-dependent decrease in the antinociceptive eff...Continue Reading

Citations

Feb 26, 2003·European Journal of Pain : EJP·Liberato BerrinoFrancesco Rossi

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