Tolerance in mixed chimerism - a role for regulatory cells?

Trends in Immunology
Josef KurtzMegan Sykes

Abstract

The establishment of mixed hematopoietic chimerism induces life-long donor-specific organ graft tolerance while obviating the need for chronic immunosuppression. Recent advances have dramatically reduced the conditioning toxicity required to achieve mixed chimerism. We argue that the achievement of high levels of donor chimerism ensures life-long deletion of donor-reactive T cells, precluding and obviating the need for regulatory mechanisms in the maintenance of tolerance. However, in situations where high levels of donor chimerism cannot be established or sustained, control of immune responsiveness can be achieved through additional mechanisms, including regulatory T cells.

References

Jan 22, 2000·The Journal of Clinical Investigation·C A HuangD H Sachs
Jun 3, 2000·Annual Review of Immunology·E M Shevach
Mar 13, 2001·Annual Review of Immunology·B Salomon, J A Bluestone
May 5, 2001·Immunity·M Sykes
Sep 19, 2001·The Journal of Clinical Investigation·A D WellsL A Turka
Jul 9, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J KurtzM Sykes
Aug 17, 2002·Current Opinion in Immunology·Thomas WekerleMegan Sykes
Oct 9, 2002·The Journal of Experimental Medicine·Yosef RefaeliAbul K Abbas
Jun 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·James E CroweRichard N Pierson
Jun 20, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Josef KurtzMegan Sykes
Jun 20, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Andrew B AdamsChristian P Larsen
Aug 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Zhong GuoKenneth A Newell
Oct 2, 2003·Nature Medicine·Herman Waldmann
Dec 18, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Yasuo TakeuchiMegan Sykes
Jun 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Luis GracaHerman Waldmann
Feb 24, 2011·Blood·Sandra N CatlinJanis L Abkowitz

❮ Previous
Next ❯

Citations

Dec 13, 2006·Clinical & Developmental Immunology·Alice LiAlan Escher
Jun 2, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Guangwei LiuYong Zhao
Oct 18, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Morvarid MoayeriRobert G Hawley
Dec 16, 2011·Journal of Molecular Cell Biology·Qizhi TangSang-Mo Kang
Jan 16, 2013·Clinical & Developmental Immunology·David A LeonardCurtis L Cetrulo
Feb 13, 2008·BMC Immunology·Tomoko DokiMary Kearns-Jonker
Dec 20, 2012·Clinical & Developmental Immunology·Kadiyala V RavindraSuzanne T Ildstad
May 19, 2010·The Journal of Surgical Research·Betul Gozel UlusalChun-Yen Lin
Oct 26, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Z SunY Zhao
Apr 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Baolin LiuZhiguang Guo
Oct 16, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Z LiA Le Moine
Oct 2, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Benjamin M HornerPeter E M Butler
Jan 31, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Paul PercoRainer Oberbauer
Aug 19, 2007·Journal of Internal Medicine·M Sykes
Oct 18, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M SchuchmannW Herr
Feb 13, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N PilatT Wekerle
May 29, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Bart Van WijmeerschBénédicte Dubois
Feb 18, 2011·Chimerism·Nina Pilat, Thomas Wekerle
May 28, 2011·Seminars in Immunology·Nina PilatThomas Wekerle
Jun 29, 2007·International Archives of Allergy and Immunology·Ines PreeThomas Wekerle
Feb 12, 2017·Stem Cells Translational Medicine·Esma S YolcuNadir Askenasy
Jun 3, 2005·Nature·Megan Sykes, Boris Nikolic
Nov 24, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana Agua-DoceLuis Graca
Sep 3, 2010·Nature Reviews. Nephrology·Nina Pilat, Thomas Wekerle
Jun 26, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kortney A RobinsonGilles Benichou
Oct 1, 2010·Current Opinion in Organ Transplantation·Nina Pilat, Thomas Wekerle
Oct 5, 2010·Current Opinion in Organ Transplantation·Maria-Carlota LondoñoAlberto Sánchez-Fueyo
Feb 28, 2006·Pediatric Transplantation·Christoph J MacheEkkehard Ring
Jan 20, 2006·Transplantation·Kenneth A NewellAllan D Kirk
Dec 18, 2009·Expert Review of Molecular Diagnostics·Josep-Maria Pujal
Jun 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ulrike BaranyiThomas Wekerle

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Sinda BigenzahnT Wekerle
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
N PilatT Wekerle
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Toshiyasu KawaharaMegan Sykes
© 2021 Meta ULC. All rights reserved