Tolerance induced by chronic inhaled antigen in a murine asthma model is not mediated by endotoxin

Biochimica Et Biophysica Acta
Craig M SchrammRoger S Thrall

Abstract

Ovalbumin (OVA)-sensitized wildtype (WT) and endotoxin-resistant (ER) mice developed similar degrees of airways eosinophilia and serum OVA-specific IgE levels after acute aerosolized OVA challenge. WT mice demonstrated methacholine hyperreactivity, whereas ER mice showed no change in responsiveness. With chronic aerosolized OVA challenge, both WT and ER mice developed local tolerance, with resolution of airway eosinophilia but persistence of anti-OVA IgE in serum. Thus, the development of local tolerance with chronic aerosol exposure to OVA is independent of any potential effects of endotoxin in the OVA aerosol solution.

References

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Sep 20, 2002·The New England Journal of Medicine·Charlotte Braun-FahrländerUNKNOWN Allergy and Endotoxin Study Team
Aug 12, 2003·The Journal of Biological Chemistry·Junji WatanabeThomas M McIntyre

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Citations

Jan 16, 2007·American Journal of Respiratory Cell and Molecular Biology·Chris L Van HoveKurt G Tournoy
Apr 15, 2008·Pulmonary Pharmacology & Therapeutics·Kristina UlrichSteven M Evans
Oct 31, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G V GuibasK N Priftis

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