Tolerance induction ameliorates allograft vasculopathy in rat aortic transplants. Influence of Fas-mediated apoptosis

The Journal of Clinical Investigation
L M AkyürekG Tufveson

Abstract

Based on successful induction of donor-specific unresponsiveness by alloantigenic stimulation in several animal models of acute rejection, we hypothesized that similar immune manipulations would also inhibit the evolution of chronic rejection and transplant vasculopathy. To induce immune tolerance, DA rats received a PVG heart allograft and were immunosuppressed with cyclosporine for 30 d. At day 100 the animals were challenged with a PVG aortic allograft after either 1 or 18 h of cold ischemia. 8 wk after the aortic transplantation, the grafts were investigated for morphological changes, infiltrating cells, apoptosis, and Fas-Fas ligand expression. Control allografts showed advanced transplant arteriosclerosis, whereas tolerance-induced aortic allografts displayed reduced neointimal formation, less medial atrophy, fewer apoptotic cells, and fewer Fas- and FasL-expressing cells. Prolonged ischemic storage time did not profoundly alter the morphological changes of the allografts. Fas expression was found in T cells, macrophages, vascular smooth muscle cells, and endothelial cells, whereas FasL was expressed mainly by T cells and macrophages. FasL mRNA expression was evident throughout the entire allograft wall. In conclusion, in...Continue Reading

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Dec 14, 1991·Lancet·G A RicaurteA L Martello
May 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·A MennanderP Häyry
Mar 1, 1994·The Journal of Experimental Medicine·T Suda, S Nagata
Jun 1, 1995·Kidney International·L C Paul
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J DrappaK B Elkon
May 1, 1995·The Journal of Clinical Investigation·M R BennettS M Schwartz
Feb 1, 1995·The Australian and New Zealand Journal of Surgery·P JablonskiN M Thomson
Jan 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·C Johnsson, G Tufveson
Jun 27, 1994·Transplantation·A Räisänen-SokolowskiP Häyry
Aug 1, 1993·Immunological Reviews·B C Fellström, E Larsson
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E G NabelR Derynck
Jun 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·M L Bochaton-PiallatG Gabbiani
Apr 5, 1996·Biochemical and Biophysical Research Communications·E NishioY Watanabe
Jan 1, 1996·International Reviews of Immunology·M H Sayegh, C B Carpenter
Oct 1, 1996·Current Opinion in Lipidology·M J MitchinsonM R Bennett
Dec 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·J WaltenbergerK Funa
Jan 15, 1997·Transplantation·J LaineL Dunkel
Jan 27, 1997·Transplantation·S D BergeseC G Orosz
Apr 21, 1997·The Journal of Experimental Medicine·P A KienerW C Liles
Oct 23, 1997·The Journal of Clinical Investigation·L L ShearsS M Pham

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Citations

Mar 27, 2001·Transplantation Proceedings·B FellströmL Zezina
Nov 22, 2001·Immunology Letters·Monika KasprzyckaAndrzej Górski
May 31, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Anne V Hall, Anthony M Jevnikar
Nov 15, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·S M EnsmingerK J Wood
Sep 17, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Chunming DongPascal J Goldschmidt-Clermont
Jan 24, 2004·BMC Cell Biology·Gerasimos FilippatosBruce D Uhal
Feb 28, 2008·Transplantation·Ruediger HoerbeltJoren C Madsen
Jun 24, 2008·Annales pharmaceutiques françaises·A Hulin
Oct 22, 2004·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Tomasz UrbanekEwa Wielgus
Jul 26, 2000·Transplantation·A J Coito, J W Kupiec-Weglinski
Jul 26, 2000·Transplantation·D PlissonnierJ B Michel
Aug 19, 2000·Transplantation·G Tufveson, C Johnsson
Aug 19, 2003·Transplantation·Johannes DonauerGerd Walz
May 26, 2001·Transplantation·B XuC D Platsoucas
Sep 18, 2002·Circulation·Tao WangPascal J Goldschmidt-Clermont
May 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K L WomerM H Sayegh
Aug 24, 1999·Current Opinion in Nephrology and Hypertension·W W Hancock
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S M EnsmingerK J Wood
Aug 9, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Thomas C TungLuyi Sen
Oct 5, 2002·Transplantation·Alexander S KrupnickBruce R Rosengard

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