Tolerance induction for solid organ grafts with donor-derived hematopoietic reconstitution

Immunologic Research
K L Gandy

Abstract

Tolerance of transplanted tissue has been a focus of immunologists for decades. Indeed, to some the birth of immunology and the search for tolerance of the non-self are synonymous. One of the most powerful and reproducible methods of tolerance induction to allogeneic tissue has involved infusion of donor-specific hematopoietic cells. Under certain conditions, such infusion can result in hematopoietic reconstitution that can be experimentally accomplished at a variety of different time-points in the life of an organism from the in utero period through adulthood, reconstitution at each time-point involving consideration of a different set of immunological and physiological parameters. When high levels of donor-derived hematopoietic reconstitution are achieved, tolerance induction to donor-specific antigens is reproducible and long-lasting. Unfortunately, however, clinical efforts to achieve such high levels of hematopoietic reconstitution have historically been unsuccessful or fraught with complications. Transplantation efforts have been plagued by failure of engraftment, graft-vs-host disease (GVHD), or severe immunoincompetence of the recipient. Laboratory and clinical efforts during the last decade have resulted in a variety o...Continue Reading

Citations

Jul 17, 2009·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Laura M MillerKaren L Fingerman
Jan 12, 2005·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Fredda Blanchard-Fields, Carolyn Beatty
Apr 13, 2018·Science Translational Medicine·Christian ChabannonChiara Bonini

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