Tolerance of arteries to microplanar X-ray beams

International Journal of Radiation Oncology, Biology, Physics
Boudewijn van der SandenJean Laissue

Abstract

The purpose is to evaluate effects of a new radiotherapy protocol, microbeam radiation therapy, on the artery wall. In previous studies on animal models, it was shown that capillaries recover well from hectogray doses of X-rays delivered in arrays of narrow (< or = 50 microm) beams with a minimum spacing of 200 microm. Here, short- and long-term effects of comparable microplanar beam configurations on the saphenous artery of the mouse hind leg were analyzed in situ by use of nonlinear optics and compared with histopathologic findings. The left hind leg of normal mice including the saphenous artery was irradiated by an array of 26 microbeams of synchrotron X-rays (50 microm wide, spaced 400 microm on center) with peak entrance doses of 312 Gy and 2,000 Gy. The artery remained patent, but narrow arterial smooth muscle cell layer segments that were in the microplanar beam paths became atrophic and fibrotic in a dose-dependent pattern. The wide tunica media segments between those paths hypertrophied, as observed in situ by two-photon microscopy and histopathologically. Clinical risks of long-delayed disruption or occlusion of nontargeted arteries from microbeam radiation therapy will prove less than corresponding risks from broad-b...Continue Reading

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Citations

Mar 3, 2012·Medical Physics·Y PrezadoM Saanchez
Jul 12, 2011·International Journal of Radiation Oncology, Biology, Physics·Sara SabatassoValentin Djonov
Oct 12, 2010·International Journal of Radiation Oncology, Biology, Physics·Audrey BouchetRaphaël Serduc
Mar 17, 2016·International Journal of Radiation Biology·Lloyd M L SmythPeter A W Rogers
Apr 25, 2012·Veterinary Ophthalmology·Jean A LaissueDaniel N Slatkin
Mar 17, 2015·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·M A GrotzerJ A Laissue
May 26, 2015·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Audrey BouchetValentin Djonov
Jan 17, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jean A LaissueDaniel N Slatkin
Jan 9, 2018·International Journal of Radiation Biology·Mihaela GhitaKevin M Prise
Nov 7, 2019·Physics in Medicine and Biology·Stefan BartzschMoeava Tehei
Feb 29, 2020·Cancers·Cristian Fernandez-PalomoValentin Djonov
Sep 4, 2015·Journal of Biosciences·Guido A Drexler, Miguel J Ruiz-Gomez
Jul 28, 2017·The British Journal of Radiology·Elisabeth SchültkeJean Laissue
Dec 22, 2020·Radiation Research·Hisanori FukunagaKevin M Prise
Jun 16, 2021·International Journal of Radiation Biology·Jean A Laissue
Aug 30, 2021·Clinical Oncology : a Journal of the Royal College of Radiologists·H FukunagaK M Prise
Oct 24, 2017··James ArcherEnbang Li

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