PMID: 6408041Jul 1, 1983Paper

Tolerance of canine anastomoses to intraoperative radiation therapy

International Journal of Radiation Oncology, Biology, Physics
J E TepperT Padikal

Abstract

Radiation has been given intraoperatively to various abdominal structures in dogs, using a fixed horizontal 11 MeV electron beam at the Armed Forces Radiobiologic Research Institute. Animals were irradiated with single doses of 2000, 3000 and 4500 rad to a field which extended from the bifurcation of the aorta to the rib cage. All animals were irradiated during laparotomy under general anesthesia. Because the clinical use of intraoperative radiotherapy in cancer treatment will occasionally require irradiation of anastomosed large vessels and blind loops of bowel, the tolerance of aortic anastomoses and the suture lines of blind loops of jejunum to irradiation were studied. Responses in these experiments were scored at times up to one year after irradiation. In separate experiments both aortic and intestinal anastomoses were performed on each animal for evaluation of short term response. Response was graded by arteriography, gastrointestinal roentgenography, blind loop bursting pressure, and pathologic findings at autopsy and microscopic evaluation. The dogs with aortic anastomoses showed adequate healing at all doses with no evidence of suture line weakening. On long-term follow-up one animal (2000 rad) had stenosis at the anas...Continue Reading

References

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Citations

Feb 1, 1992·Diseases of the Colon and Rectum·T J SaclaridesM S Bapna
Sep 1, 1986·International Journal of Radiation Oncology, Biology, Physics·J E TepperJ K Martin
Mar 1, 1996·International Journal of Radiation Oncology, Biology, Physics·P A JohnstoneW F Sindelar
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