PMID: 3130689Jan 1, 1987Paper

Tolerance of Kenyan Schistosoma mansoni to oxamniquine

Transactions of the Royal Society of Tropical Medicine and Hygiene
G C ColesN Katz


Although 30 mg/kg oxamniquine produced high levels (85.5 to 99.5%) of egg reduction in Kenyan children infected with Schistosoma mansoni after a single oral treatment, cure rates from children at Mwea in Kirinyaga district were lower than those from Machakos (58% v. 74%). Redosing uncured children confirmed this lower cure rate (36% v. 83%). Isolates from infected children were passaged into mice and dosed with oxamniquine. Lower than expected reductions in worm numbers were obtained, suggesting that oxaminiquine tolerant S. mansoni are present in the normal worm population in Kenya. It is concluded that mass use of oxamniquine at 30 mg/kg may produce problems of drug resistance.


Jan 1, 1976·Transactions of the Royal Society of Tropical Medicine and Hygiene·R CamposL C Da Silva
Feb 1, 1987·International Journal for Parasitology·G C Coles, J I Bruce
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·G C ColesN Katz
Jan 1, 1973·Transactions of the Royal Society of Tropical Medicine and Hygiene·R Foster, B L Cheetham
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·A E ButterworthR F Sturrock
Sep 1, 1980·The American Journal of Tropical Medicine and Hygiene·N AraujoC P de Souza
Jan 1, 1962·The American Journal of Tropical Medicine and Hygiene·J I BRUCEM J SCHOENBECHLER
Jul 1, 1986·Parasitology Today·P J Waller

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