Tolerance of mefloquine alone and in combination with sulfadoxine-pyrimethamine in the prophylaxis of malaria

Transactions of the Royal Society of Tropical Medicine and Hygiene
E C ReisingerM Dietrich

Abstract

A randomized double blind study was performed to evaluate the tolerance and the acceptance of mefloquine alone (Lariam) compared to a combined drug regimen consisting of mefloquine, sulfadoxine and pyrimethamine (MSP; Fansimef) in the prophylaxis of malaria. 175 Europeans travelling to different malaria endemic areas received either mefloquine alone (250 mg/week) or its combination with sulfadoxine (500 mg/week) plus pyrimethamine (25 mg/week). One person taking mefloquine and two taking MSP discontinued the drug intake because of moderate clinical side effects. Mild and moderate adverse clinical reactions predominantly concerning the gastro-intestinal tract and the autonomous nervous system were reported with a significantly higher occurrence in the MSP group. With both prophylactic regimens, reversibly elevated liver enzyme activities (glutamate oxalate transaminase and glutamate pyruvate transaminase [GPT]) were observed after prophylaxis. The increase of GPT serum activity correlated significantly with relatively high GPT levels before prophylaxis in both groups. This finding suggests a limited use of both regimens in cases of liver dysfunction. One case of mefloquine-resistant Plasmodium falciparum malaria was observed fro...Continue Reading

References

Dec 1, 1977·Annals of Tropical Medicine and Parasitology·W PetersD C Warhurst
Mar 1, 1976·Antimicrobial Agents and Chemotherapy·D F ClydeR B Hornick
Nov 21, 1975·Science·C M TrenholmeC J Canfield
Jan 1, 1988·Transactions of the Royal Society of Tropical Medicine and Hygiene·W M WatkinsR E Howells
Mar 1, 1987·Molecular and Biochemical Parasitology·C PinswasdiK Pavanand
Aug 15, 1985·The New England Journal of Medicine·D W MacPherson, J S Keystone
Apr 12, 1974·Deutsche medizinische Wochenschrift·H SchlebuschM Knedel
Oct 1, 1971·Journal of Medicinal Chemistry·C J OhnmachtR E Lutz
Jan 1, 1981·Antibiotics and Chemotherapy·M Dietrich, P Kern
Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·L J Bruce-Chwatt
Jun 2, 2010·Clinics in Laboratory Medicine·Lynne S Garcia

❮ Previous
Next ❯

Citations

Feb 3, 1999·Lancet·A GriecoG Gasbarrini
Nov 1, 1994·Postgraduate Medical Journal·G C Cook
Dec 29, 2000·Pharmacotherapy·I GotsmanE Ben-Chetrit
Oct 2, 2015·Journal of Travel Medicine·Andrew G TerrellDavid A Ross
Dec 1, 1996·Journal of Travel Medicine·M Dietrich
Apr 13, 2012·Travel Medicine and Infectious Disease·Remington L Nevin
Feb 7, 2008·The Cochrane Database of Systematic Reviews·A M J Croft, P Garner
Oct 31, 2017·The Cochrane Database of Systematic Reviews·Maya Tickell-PainterDavid Sinclair

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

Bulletin of the World Health Organization
E B DoberstynC Teerakiartkamjorn
The Southeast Asian Journal of Tropical Medicine and Public Health
K Na BangchangT Harinasuta
The Southeast Asian Journal of Tropical Medicine and Public Health
D BunnagD Stürchler
© 2021 Meta ULC. All rights reserved