Tolerance of mouse macrophages in vitro to barium sulfate used in orthopedic bone cement

Journal of Biomedical Materials Research
T Rae

Abstract

Barium sulfate, used as a radio-opaque marker in some orthopedic bone cements, has been shown to escape into the surrounding tissues. This may present a potential hazard. In particular, phagocytic cells may be exposed to relatively high internal levels of barium once the particles have been phagocytosed. Mouse peritoneal macrophages exposed to barium sulfate for periods up to 144 hr showed a marked cytoplasmic vacuolization from which they recovered only partially. Barium sulfate did not appear to damage the cell membrane as judged by lactice dehydrogenase release. In the relatively low doses and with the periods of exposure described here, barium sulfate does not appear to present a serious toxic hazard in the short term. It is possible, however, that longer exposures and larger doses may result in the death of phagocytic cells which have ingested barium sulfate.

References

Apr 29, 1967·Nature·G Macnab, J S Harington
Jan 1, 1971·The Journal of Experimental Medicine·W R Wallingford, D J McCarty
Apr 1, 1971·Environmental Research·J S HaringtonG Macnab

Citations

Jan 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H I Roach
Jul 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M D LazarusD G Baker
Jan 1, 1991·Biomaterials·L A ThomsonJ Franks
Oct 1, 1995·Biomaterials·D GranchiA Pizzoferrato
Jan 17, 2002·Biomaterials·D GranchiArmando Giunti
Sep 2, 2003·Journal of Neuroscience Methods·Hua AiXiaoxi Qiao
Nov 1, 1992·Arthritis and Rheumatism·S YamamotoT Yamamuro
Feb 25, 2009·Journal of Microencapsulation·Roche C de GuzmanPamela J VandeVord
Sep 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Żaneta GóreckaWojciech Swięszkowski

Related Concepts

Barium Sulfate (2: 1)
Bone Cements
Plasma Membrane
Lactate Dehydrogenase
Macrophage
Phagocytosis

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