Tolerance of platelet concentrates treated with UVC-light only for pathogen reduction--a phase I clinical trial

Vox Sanguinis
Thomas ThieleAxel Seltsam

Abstract

The THERAFLEX UV-Platelets pathogen reduction system for platelet concentrates (PCs) operates with ultraviolet C light (UVC; 254 nm) only without addition of photosensitizers. This phase I study evaluated safety and tolerability of autologous UVC-irradiated PCs in healthy volunteers. Eleven volunteers underwent two single (series 1 and 2) and one double apheresis (series 3). PCs were treated with UVC, stored for 48 h and retransfused in a dose-escalation scheme: 12·5, 25% and 50% of a PC (series 1); one complete PC (series 2); two PCs (series 3). Platelet counts, fibrinogen, activated partial thromboplastin time, prothrombin time, D-dimer, standard haematology, temperature, heart rate, blood pressure and clinical chemistry parameters were measured. One- and 24-h corrected count increments were determined in series 2 and 3. Platelet-specific antibodies were assessed before and at the end of the study. Neither adverse reactions related to transfusions nor antibodies against UVC-treated platelets were observed. Corrected count increments did not differ between series 2 and 3. Repeated transfusions of autologous UVC-treated PCs were well tolerated and did not induce antibody responses in all volunteers studied. EudraCT No. 2010-023...Continue Reading

References

Jun 1, 1978·British Journal of Haematology·A E von dem BorneC P Engelfriet
Sep 1, 1992·Transfusion Medicine·V Kiefel
Sep 8, 1994·The New England Journal of Medicine·N M HeddleJ G Kelton
Jan 7, 1998·The New England Journal of Medicine·UNKNOWN Trial to Reduce Alloimmunization to Platelets Study Group
Mar 29, 2003·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Rajeshwar P Sinha, Donat P Häder
Jan 27, 2004·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Michael J Davies
Feb 14, 2004·Transfusion·Boris ZavizionBernadette Alford
Mar 8, 2005·Mutation Research·Jean CadetThierry Douki
Apr 12, 2005·Transfusion·P A W te BoekhorstD J van Rhenen
Jul 14, 2006·Transfusion·Fabrice CognasseOlivier Garraud
May 31, 2008·British Journal of Haematology·Eldad Hod, Joseph Schwartz
Jul 23, 2011·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Axel Seltsam, Thomas H Müller
May 29, 2013·British Journal of Haematology·Axel Seltsam, Thomas H Müller

❮ Previous
Next ❯

Citations

Apr 27, 2016·Hematology/oncology Clinics of North America·Dana V Devine, Peter Schubert
Aug 1, 2016·La Presse médicale·Miguel Lozano, Joan Cid
May 20, 2017·Platelets·Audrey MagronEric Boilard
Aug 10, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Arno WieheMathias O Senge
Aug 9, 2020·Platelets·Joels Wilson-NieuwenhuisNina Dempsey-Hibbert
Apr 3, 2015·Thrombosis and Haemostasis·Andreas GreinacherKathleen Selleng
Jun 23, 2018·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Oct 28, 2018·Critical Care : the Official Journal of the Critical Care Forum·Jerrold H LevyJay H Herman
Feb 23, 2019·Transfusion·Lauren WatersLacey Johnson
Nov 19, 2019·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Thierry BurnoufJerard Seghatchian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.