Tolerance of the newborn to antiretroviral drug exposure in utero

Expert Opinion on Drug Safety
Jeanne SibiudeS Blanche

Abstract

The prevention of mother-to-child HIV-1 transmission by antiretroviral drug treatment is remarkably effective. The risk of transmission to the child is now almost zero for women optimally treated during pregnancy. The rapid expansion of this prophylactic treatment has led the World Health Organization to aspire to the virtual elimination of mother-to-child transmission and pediatric AIDS over the next few years. In 2014, more than 900,000 women worldwide were treated with antiretroviral drugs during pregnancy. The issue of fetal and neonatal antiretroviral drug tolerance is therefore extremely important. This review focuses on the possible impact of in utero exposure to antiretroviral drug on newborn health. To restrict analysis to this period is justified by the specificities of transplacental drug exposure and fetal vulnerability. Relevant data are available from trials and observational cohorts. The significance of various bio-markers detectable at birth is still unresolved, but merits a careful evaluation. Long-term assessment is associated with various logistical difficulties. The health of 'exposed but not infected' children poses no major problem in the immense majority of cases, but a series of biological, clinical and ...Continue Reading

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Citations

Feb 1, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jeanne SibiudeUNKNOWN ANRS-French Perinatal Cohort Study Group
Feb 2, 2017·Archives of Trauma Research·Ali MoradiEnsiyeh Jamshidi
Jun 19, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Luc BertrandMichal Toborek

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