PMID: 11906661Mar 22, 2002Paper

Tolerance of the rabbit cornea to an n-butyl-ester cyanoacrylate adhesive (Vetbond)

Veterinary Ophthalmology
F OllivierA Regnier

Abstract

An n-butyl-ester cyanoacrylate adhesive available for veterinary surgery (Vetbond, 3M) was tested in rabbits for corneal irritation. Two experimental procedures were used on 24 rabbits: injection of the adhesive into an intralamellar corneal pocket (n = 10) and application of the glue to a mid-stromal corneal defect (n = 14). In both experiments the eyes were examined for 20 days for evidence of corneal irritation and tolerance. At the end of each experiment, histopathologic studies were performed on all corneas. The corneal reaction to the intrastromally injected cyanoacrylate was characterized clinically by slight edema and vascularization localized to the vicinity of the adhesive. A moderate foreign body-type reaction was found histologically. Following application of the adhesive to a central stromal defect, the treated corneas remained totally clear and histopathologic examination showed that the healing process was not altered compared to the controls. The mean retention time of the glue patch was 14 days. Intrastromal injection and surface application to a corneal defect of n-butyl-ester cyanoacrylate to a corneal defect induced only a mild inflammatory response and did not interfere with the reparative process. These fi...Continue Reading

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Citations

Jun 28, 2006·Diabetes Technology & Therapeutics·Praveen ThoniyotBakthan Singaram
Aug 18, 2004·Veterinary Ophthalmology·Christine M WattéGillian J McLellan
Jul 16, 2011·Lasers in Surgery and Medicine·Ying WangMin Yao
Dec 17, 2010·Journal of Pediatric Ophthalmology and Strabismus·Suqin GuoAnthony Caputo

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