PMID: 6979047Mar 1, 1982Paper

Tolerance of thymic cytotoxic T lymphocytes to allogeneic H-2 determinants encountered prethymically: evidence for expression of anti-H-2 receptors prior to entry into the thymus

Proceedings of the National Academy of Sciences of the United States of America
P J MorrisseyA Singer

Abstract

This study has assessed the possibility that anti-H-2 receptors are expressed on T-cell precursors prior to their entry into the thymus. Parental strain A thymus was transplanted into either normal or thymectomized (A x B)F1 mice which were then irradiated and reconstituted with strain A bone marrow. The cells repopulating the engrafted strain A thymus were shown to be of donor bone marrow origin. Thus, strain A thymocytes were differentiating within a syngeneic thymus, after exposure to allogeneic strain B major histocompatibility complex (MHC) determinants of the irradiated F1 host. The cells repopulating the engrafted thymus were assessed for their ability to generate alloreactive cytotoxic T lymphocyte responses and were found to be specifically tolerant to allogeneic strain B MHC determinants. This tolerance existed in the absence of detectable suppression and in the absence of detectable strain B MHC determinants intrathymically. These data are most consistent with the concept that precursor T cells express anti-MHC receptors prior to their entry into the thymus and that exposure to MHC determinants prethymically results in their functional inactivation.

References

Jan 1, 1976·Scandinavian Journal of Immunology·C A JanewayH Binz
Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Aug 6, 1981·Nature·P Matzinger
Sep 1, 1980·The Journal of Experimental Medicine·T Hünig, M J Bevan
Jan 1, 1971·European Journal of Immunology·N K Jerne

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Citations

May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M F GoodG J Nossal
May 1, 1988·The Journal of Experimental Medicine·G J SpangrudeI L Weissman
Jan 1, 1989·The Journal of Experimental Medicine·M BoguniewiczY Borel
Apr 15, 1990·Cellular Immunology·P BenvenisteR G Miller
Dec 1, 1989·Cellular Immunology·G BiasiH Festenstein
Jun 1, 1986·Immunological Reviews·O Stutman
Jul 1, 1984·The American Journal of Anatomy·G J Nossal
Jul 1, 1984·The American Journal of Anatomy·J J Owen, E J Jenkinson

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