Tolerance to ethanol analgesia is not accompanied by cross-tolerance to morphine analgesia in rats

Pharmacology, Biochemistry, and Behavior
R L BellA L Vaccarino

Abstract

In the present study, we examined the development of environment-independent and environment-dependent tolerance to ethanol-induced analgesia (EIA) and cross-tolerance with morphine-induced analgesia (MIA). To examine the development of environment-independent tolerance, male Long-Evans rats were given increasing amounts of ethanol (5 days each of 5% (v/v), 10% (v/v), and 15% (v/v)) added to their drinking water over a 15-day period. A control group was given plain tap water to drink. On day 16, all rats were given plain tap water to drink. On day 17, the animals were tested for EIA (2.5 g/kg, I.P.) or MIA (10 mg/kg, I.P.) in the hot plate test. To examine the development of environment-dependent tolerance, animals were injected with ethanol (2.5 g/kg, I.P.) or an equal volume of saline once a day for 2 days. On day 3, the animals received no treatment. On day 4, the animals were tested for either EIA (2.5 g/kg, I.P.) or MIA (10 mg/kg, I.P.) in the hot plate test. It was found that rats pretreated with ethanol (both self-administration and I.P. injections) displayed tolerance to EIA, which was not accompanied by cross-tolerance to MIA.

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Citations

Oct 24, 2003·Life Sciences·Gustavo Hauber GameiroMaria Cecília Ferraz de Arruda Veiga
Jun 1, 2005·Life Sciences·Laura Climent PerisJosé Francisco Horga de la Parte
Nov 6, 2007·Life Sciences·Marília Bertoldo UrtadoMaria Cecília Ferraz de Arruda Veiga

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