Tolerance to Gamma Radiation in the Tardigrade Hypsibius dujardini from Embryo to Adult Correlate Inversely with Cellular Proliferation

PloS One
Eliana Beltrán-PardoAndrzej Wojcik

Abstract

Tardigrades are highly tolerant to desiccation and ionizing radiation but the mechanisms of this tolerance are not well understood. In this paper, we report studies on dose responses of adults and eggs of the tardigrade Hypsibius dujardini exposed to gamma radiation. In adults the LD50/48h for survival was estimated at ~ 4200 Gy, and doses higher than 100 Gy reduced both fertility and hatchability of laid eggs drastically. We also evaluated the effect of radiation (doses 50 Gy, 200 Gy, 500 Gy) on eggs in the early and late embryonic stage of development, and observed a reduced hatchability in the early stage, while no effect was found in the late stage of development. Survival of juveniles from irradiated eggs was highly affected by a 500 Gy dose, both in the early and the late stage. Juveniles hatched from eggs irradiated at 50 Gy and 200 Gy developed into adults and produced offspring, but their fertility was reduced compared to the controls. Finally we measured the effect of low temperature during irradiation at 4000 Gy and 4500 Gy on survival in adult tardigrades, and observed a slight delay in the expressed mortality when tardigrades were irradiated on ice. Since H. dujardini is a freshwater tardigrade with lower tolerance...Continue Reading

References

Sep 12, 2000·Molecular Biology of the Cell·N C KappasJ C Sible
Mar 27, 2003·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Donat P HäderE Walter Helbling
Mar 29, 2003·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Rajeshwar P Sinha, Donat P Häder
Sep 18, 2003·Physiological and Biochemical Zoology : PBZ·K Ingemar Jönsson
Jan 9, 2004·Current Biology : CB·Patrick H O'FarrellTin Tin Su
Dec 22, 2005·International Journal of Radiation Biology·K Ingemar JönssonJesper Torudd
Mar 22, 2006·The Journal of Cell Biology·Antonia H HolwayW Matthew Michael
Dec 15, 1955·Proceedings of the National Academy of Sciences of the United States of America·M L Alexander, W S Stone
Dec 21, 2006·International Journal of Radiation Biology·Daiki D HorikawaMikinori Kuwabara
Jan 31, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·K Ingemar Jönsson, Ralph O Schill
Oct 30, 2007·Astrobiology·K Ingemar Jönsson
Nov 13, 2007·Developmental Biology·Willow N GabrielBob Goldstein
Sep 13, 2008·Current Biology : CB·K Ingemar JönssonPetra Rettberg
Mar 3, 2009·The Journal of Experimental Biology·Alexander G McLennan
Apr 14, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Simon NeumannRalph O Schill
Apr 20, 2010·International Journal of Radiation Biology·E J Charlotta NilssonJan Pallon
Mar 5, 2011·Microbiology and Molecular Biology Reviews : MMBR·Dea Slade, Miroslav Radman
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Anita KriskoMatthew Meselson
Jan 29, 2014·International Journal of Radiation Biology·Halina LisowskaAndrzej Wojcik

Citations

Dec 20, 2019·International Journal of Radiation Biology·Dietrich AverbeckLaure Sabatier
Aug 28, 2020·Frontiers in Microbiology·Boris HespeelsKarine Van Doninck
Nov 3, 2018·Cold Spring Harbor Protocols·Bob Goldstein
Dec 3, 2020·International Journal of Radiation Biology·Jagdish Gopal PaithankarRajashekhar K Patil
Nov 17, 2020·Frontiers in Physiology·Jonathan D HibshmanBob Goldstein

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis