PMID: 46268Feb 1, 1975

Tolerance to histocompatibility determinants in tetraparental bone marrow chimeras

The Journal of Experimental Medicine
H V BoehmerM Nabholz

Abstract

Tetraparental bone marrow chimeras were produced by injecting lethally X-irradiated F1 hybrids with relatively high numbers of T-cell-depleted bone marrow cells from both allogeneic parental strains. The mice survival in excellent health and showed a stable, approximately 50:50 (parent:parent), lymphoid cell chimerism lasting for at least 7 mo after irradiation; regeneration of host-type hemopoietic cells was very limited. Thymus, lymph node, and thoracic duct lymphocytes showed specific unresponsiveness to host mixed leukocyte reaction (MLR) determinants. Similarly specific tolerance to H-2 antigens of host type was demonstrated in spleen and lymph node. No suppressor cells could be demonstrated in either system and blocking serum factors could not be found. The results suggest specific deletion of functional T cells reactive to host-type MLR and cell-mediated lympholysis determinants.

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Citations

Jan 1, 1981·Immunogenetics·M BrenanA Müllbacher
Aug 1, 1980·Springer Seminars in Immunopathology·J SprentK Molnar-Kimber
May 1, 1977·Cellular Immunology·C M WarnerJ L McIvor
Jan 1, 1979·Journal of Immunological Methods·P ChandlerE Simpson
Jan 1, 1996·Immunology Letters·R A MannA B Singh
May 21, 2008·Nature Immunology·H von Boehmer
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T Matsunaga, E Simpson
May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·V Kumar, M Bennett
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G J Nossal, B L Pike
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K IwabuchiK Onoé
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B P GiroirB Beutler
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·N S el Badri, R A Good
Dec 1, 1975·The Journal of Experimental Medicine·P H KrammerJ Sprent
Apr 1, 1978·The Journal of Experimental Medicine·H von BoehmerH Pohlit
Nov 1, 1979·The Journal of Experimental Medicine·H von Boehmer, W Haas
Apr 7, 2007·The Journal of Experimental Medicine·Hema Bashyam
Apr 1, 1993·British Journal of Haematology·A Fischer
Jan 1, 1978·Scandinavian Journal of Immunology·R M GroczynskiJ E Till
Oct 14, 2006·Annals of the Rheumatic Diseases·H von Boehmer
Aug 1, 1987·The American Journal of the Medical Sciences·R A Good
Dec 20, 2015·British Journal of Haematology·Noga Or-Geva, Y Reisner
Jan 18, 2011·Hematology/oncology Clinics of North America·Joel M RappeportRobertson Parkman
Feb 2, 2010·Immunology and Allergy Clinics of North America·Joel M RappeportRobertson Parkman
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Oct 20, 1977·Differentiation; Research in Biological Diversity·C M WarnerT J Stephens
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Mar 29, 2003·Blood·Takanori TeshimaJames L M Ferrara
Mar 17, 2004·Cancer Control : Journal of the Moffitt Cancer Center·Timothy F Goggins, David R Rizzieri
Feb 1, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lucia GuerriOlivier Lantz
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Jul 1, 1977·European Journal of Immunology·H von BoehmerW Haas
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Feb 1, 1976·European Journal of Immunology·P H KrammerH von Boehmer
Nov 1, 1979·European Journal of Immunology·H von BoehmerW Haas
Dec 29, 1995·Annals of the New York Academy of Sciences·R A Good

Related Concepts

Immune complex
Antigenic Specificity
Marrow
Bone Marrow Cells
Chimera Organism
Microcytotoxicity Test
SD Antigens
Natural Immunosuppression
Lymphocyte Culture Test, Mixed
Mice, Inbred CBA

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