PMID: 1203629Nov 1, 1975Paper

Tolerance to morphine-induced calcium depletion in regional brain areas: characterization with reserpine and protein synthesis inhibitors

British Journal of Pharmacology
D H Ross

Abstract

1 Administration of a single dose of morphine sulphate (25 mg/kg) induces tolerance to calcium depletion lasting seven days. 2 There are no apparent changes in calcium content in any of eight discrete brain regions throughout this seven day period. 3 Pretreatment with reserpine (5 mg/kg) did not alter the ability of morphine to induce tolerance. Reserpine alone produced no tolerance to its own calcium depleting action. 4 Cycloheximide (500 mug/kg) but not chloramphenicol (200 mg/kg) effectively prevented development of tolerance. 5 It is concluded that the induction of tolerance to calcium depletion seen after morphine may involve changes in various proteins in membranes of synaptic origin.

References

Mar 1, 1975·Journal of Neurochemistry·H L Cardenas, D H Ross
Jan 1, 1974·Annual Review of Biochemistry·S H Barondes
Jan 1, 1968·Journal of Neurochemistry·I G Morgan, L Austin
Feb 1, 1972·CRC Critical Reviews in Biochemistry·H RasmussenA Tenenhouse
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·C B Pert, S H Snyder
Nov 15, 1972·Biochemical Pharmacology·M P Feinberg, J Cochin
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Nov 1, 1968·British Journal of Pharmacology·W W Douglas
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Jun 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·M COHENG UNGAR

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Citations

Sep 1, 1978·Neuropharmacology·F C ColpaertP A Janssen
Aug 1, 1976·British Journal of Pharmacology·H L Cardenas, D H Ross
Feb 1, 1988·Neurochemical Research·L Rönnbäck, E Hansson
Mar 1, 1979·Journal of Neurochemistry·W K Schmidt, E L Way
Apr 1, 1979·Alcoholism, Clinical and Experimental Research·W O BogganD L Sparks
Apr 15, 1977·Life Sciences·D H Ross, H L Cardenas

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