PMID: 1212562Dec 1, 1975Paper

Tolerance to sympathomimetic bronchodilators in guinea-pig isolated lungs following chronic administration in vivo

British Journal of Pharmacology
C J BenoyO L Wade

Abstract

1 Pretreatment of the guinea-pig subcataneously three times daily with either 5 mug/kg isoprenaline or adrenaline reduced the response of the isolated perfused histamine-constricted lung when challenged with either the same or a different sympathomimetic bronchodilator. The longer the animals were pretreated and the higher the dose of bronchodilator the greater was the degree of tolerance developed. 2 Tolerance was developed to aminophline in the same preparation when the guinea-pig had been pretreated with aminophyline or isoprenaline. Cross-tolerance also developed adrenaline when the guinea-pig had been pretreated with aminophyline. 3 Tolerance was still persistent in guinea-pigs one and two weeks after pretreatment three times daily with either isoprenaline of adrenaline (5 mu/kg s.c.) for seven days in the same preparation. Only after three weeks was the tolerance diminished. 4 These results suggest that asthmatic patients who use bronchodilators excessively may become refractory to the bronchodilator effect of these drugs. They also support the hypothesis that induced cross-resistance to endogenous sympathetic stimulation could lead to a deterioration of the asthmatic state in patients using the sympathomimetic bronchodil...Continue Reading

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Citations

Apr 7, 1977·European Journal of Pharmacology·J S DouglasA Bouhuys
Apr 8, 1983·European Journal of Pharmacology·J C WilliamsR E Giles
Mar 16, 1984·European Journal of Pharmacology·M J Ward, D R Tomlinson
Nov 22, 1988·European Journal of Pharmacology·M S ElfellahJ L Reid
Jan 1, 1982·International Journal of Immunopharmacology·W J WieczorekE S Assem
Mar 1, 1976·British Journal of Pharmacology·A A Anderson, G M Lees
Jan 1, 1988·Pharmacology & Toxicology·R G AnderssonI Salomonsson
Nov 1, 1987·Clinical and Experimental Dermatology·C B Archer
Apr 1, 1976·The Journal of Pharmacy and Pharmacology·W C Bowman, C Raper
Jul 1, 1980·Acta Pharmacologica Et Toxicologica·S R Johansson, R G Andersson
Nov 1, 1980·British Journal of Clinical Pharmacology·C Davis, M E Conolly
Oct 1, 1976·British Journal of Pharmacology·C R Gardner, S W Phillips
Oct 1, 1981·Acta Pharmacologica Et Toxicologica·S R Johansson, R G Andersson
Oct 31, 1980·Biochemical and Biophysical Research Communications·E Kaukel, B Rieckenberg

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