Tolerogenic dendritic cells in the control of autoimmune neuroinflammation: an emerging role of protein-glycan interactions

Neuroimmunomodulation
Juan M Ilarregui, Gabriel A Rabinovich

Abstract

During the past decade, a great deal of information has contributed to our understanding of the immunosuppressive pathways that operate during the resolution of autoimmune pathology, including central nervous system (CNS) inflammation. Activation of these pathways is accomplished through the integration of an intricate network of inhibitory signals and immune suppressive cells, including regulatory T cells, myeloid-derived suppressor cells, 'alternatively activated' macrophages and tolerogenic dendritic cells (DCs). During the course of inflammatory diseases, immature or mature DCs may be licensed by different stimuli (e.g. cytokines, neuropeptides and growth factors) to become tolerogenic and suppress pathogenic T cell responses, thus emphasizing the outstanding plasticity of these cells. Recent findings have shed light to an immunoregulatory circuit by which galectin-1, an endogenous glycan-binding protein, favors the differentiation of regulatory DCs which promote T cell tolerance and contribute to resolution of autoimmune pathology through mechanisms involving IL-27 and IL-10. Together with the ability of galectin-1-glycan interactions to selectively blunt T helper (Th)1 and Th17 responses, this effect provides a rational e...Continue Reading

Citations

Dec 25, 2010·Journal of Clinical Immunology·Juan P CerlianiGabriel A Rabinovich
Jun 12, 2013·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Galina V ShurinMichael R Shurin
Aug 19, 2011·Biochemistry·Santiago Di LellaGabriel A Rabinovich
Dec 29, 2012·International Journal of Molecular Sciences·Mohammad G MohammadDavid A Brown
Jun 23, 2011·Expert Review of Vaccines·Byram W Bridle
Apr 8, 2011·Expert Review of Neurotherapeutics·Tina VerschuereStefaan W Van Gool
Sep 10, 2015·FEBS Letters·Ada G BlidnerGabriel A Rabinovich
Aug 1, 2015·Journal of Reproductive Immunology·Fernando Gómez-ChávezSandra Rodríguez-Martínez
Aug 10, 2013·International Journal of Cancer. Journal International Du Cancer·Tina VerschuereSteven De Vleeschouwer
Feb 8, 2011·International Immunopharmacology·Iván D MascanfroniGabriel A Rabinovich
May 12, 2017·Biochemistry·Patrick K ChaffeyZhongping Tan
Dec 31, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Po-Lin KuoMing-Shyan Huang
Jan 18, 2012·Oncotarget·Florence LefrancRobert Kiss
Jul 29, 2015·The Journal of Biological Chemistry·Sandra ThiemannLinda G Baum
Mar 9, 2021·Frontiers in Immunology·Charlotte CastenmillerYvette van Kooyk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.