Tolerogenic effect of mouse fibroblasts on dendritic cells

Immunology
Mohsen Khosravi-MaharlooeiAziz Ghahary

Abstract

There is controversy about the immunomodulatory effect of fibroblasts on dendritic cells (DCs). To clarify this issue, in this study, we have evaluated different features of fibroblast-primed DCs including their ability to express co-inhibitory and co-stimulatory molecules, pro-inflammatory and anti-inflammatory cytokines and their ability to induce T-cell proliferation. We also examined migratory capacity of DCs to lymphatic tissues and present fibroblast-derived antigens after encountering fibroblasts. The results of our in vitro study showed that both co-inhibitory (programmed death ligand 1 and ligand 2 and B7H4) and co-stimulatory (CD86) molecules were up-regulated when DCs were co-cultured with fibroblasts. In an animal model, we showed that intra- peritoneal injection (IP) of both syngeneic and allogeneic fibroblasts significantly increased both total DC count and expression level of co-inhibitory and co-stimulatory molecules on DCs. Priming of DCs with syngeneic and allogeneic fibroblasts reduced the proliferation of CD4(+) and CD8(+) T cells. Even activation of fibroblast- primed DCs failed to restore their ability to induce T-cell proliferation. Likewise, priming of DCs with fibroblasts blocked the ability of ovalbumi...Continue Reading

References

Feb 1, 1975·The Australian Journal of Experimental Biology and Medical Science·K J Lafferty, A J Cunningham
Mar 11, 2000·Immunology·S BehboudiJ Austyn
Mar 20, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T FukaoS Koyasu
Feb 27, 2003·Immunology·Rolande BerthierPatrice Noël Marche
Mar 5, 2003·Annual Review of Immunology·Ralph M SteinmanMichel C Nussenzweig
Aug 7, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew L MellorDavid H Munn
Oct 4, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Benjamin D EhstMarc K Jenkins
Jan 17, 2004·Journal of Leukocyte Biology·Alessandra Mazzoni, David M Segal
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anja SaalbachJan C Simon
Jul 14, 2007·Nature Reviews. Immunology·Adrian E Morelli, Angus W Thomson
Nov 17, 2007·Molecular and Cellular Biochemistry·Farshad ForouzandehAziz Ghahary
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yin-Ping LiAssia Eljaafari
May 12, 2009·Immunological Reviews·Kyung H Yi, Lieping Chen
Aug 28, 2009·The Journal of Investigative Dermatology·Anja SaalbachJan C Simon
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·David G BrooksMichael B A Oldstone
Nov 9, 2010·Advances in Immunology·Roberto A Maldonado, Ulrich H von Andrian
Jan 1, 2010·Biological Procedures Online·Alireza Moeen RezakhanlouAziz Ghahary
Apr 14, 2011·Self/nonself·Govindarajan ThangaveluColin C Anderson
Oct 1, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sabrina ChiesaAntonio Uccelli
Jun 11, 2014·Immunology and Cell Biology·Karen O DixonCees van Kooten

❮ Previous
Next ❯

Citations

May 16, 2018·Cell Transplantation·Sanam Salimi ElizeiAziz Ghahary
Jun 21, 2016·Oncotarget·Carmen CriscitielloGiuseppe Curigliano
Nov 19, 2019·Advances in Wound Care·Mohammadreza PakyariAziz Ghahary
Apr 30, 2017·Cancer Immunology, Immunotherapy : CII·Hong JiangDavid G DeNardo
Feb 22, 2021·Journal of Autoimmunity·Mohsen Khosravi-MaharlooeiMegan Sykes
Jun 13, 2021·Acta Biomaterialia·Laura AlderferDonny Hanjaya-Putra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Tina L SumpterChandrashekhar R Gandhi
International Immunopharmacology
Hemn MohammadpourMohammad Taher Tahoori
Journal of the American Society of Nephrology : JASN
Kristy L EdgttonA Richard Kitching
The Journal of Immunology : Official Journal of the American Association of Immunologists
Tracey L PapenfussCaroline C Whitacre
© 2022 Meta ULC. All rights reserved